Team:Freiburg Bioware
From 2010.igem.org
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<!---Box on the upper right: BioBricks---> | <!---Box on the upper right: BioBricks---> | ||
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- | + | <h2>BioBricks</h2> | |
<a href="https://2010.igem.org/Team:Freiburg_Bioware/BioBricks"><img src="https://static.igem.org/mediawiki/2010/5/5f/Freiburg10_Virus_Logo_Small.png" id="ccc" /></a> | <a href="https://2010.igem.org/Team:Freiburg_Bioware/BioBricks"><img src="https://static.igem.org/mediawiki/2010/5/5f/Freiburg10_Virus_Logo_Small.png" id="ccc" /></a> | ||
- | <p class="standard">Modularisation and Modification of the viral tropismn and the effector function resulted in many different BioBricks.<br> Click here to explore them.</p | + | <p class="standard">Modularisation and Modification of the viral tropismn and the effector function resulted in many different BioBricks.<br> Click here to explore them.</p> |
</div> | </div> | ||
Revision as of 21:11, 9 October 2010
Gene delivery using viral vectors holds great promise for the treatment of acquired and inherited diseases. The human Adeno-Associated Virus (AAV) is a small, non-pathogenic, single-stranded DNA virus gaining increasing attention being both versatile and effective. Taking current knowledge into account, we generated a recombinant, modularized, BioBrick-compatible AAV ‘Virus Construction Kit’. We provide parts for modified capsid proteins, targeting modules, tumor-specific promoters, and prodrug-activating enzymes as well as readily assembled vectors for gene delivery and production of non-replicative virus particles. The viral tropism is altered by N-terminal fusion or by loop replacement of the capsid proteins. Functionality of viruses constructed from our kit was demonstrated by fluorescent protein expression in infected cells and by prodrug-induced killing of tumor cells upon viral delivery of a thymidine kinase. Incorporating multiple layers of safety, we provide a general tool to the growing field of personalized medicine and demonstrate its use in tumor therapy.
Project Results
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This Site is in Construction, later you will find more right here...[more]
Heading:
This Site is in Construction, later you will find more right here...[Klick for more]
Head-Line:
This Site is in Construction, later you will find more right here...[Klick for more]
Virus Construction Kit
Heading:
This Site is in Construction, later you will find more right here...[more]
Heading:
This Site is in Construction, later you will find more right here...[Klick for more]
Head-Line:
This Site is in Construction, later you will find more right here...[Klick for more]
BioBricks
Modularisation and Modification of the viral tropismn and the effector function resulted in many different BioBricks.
Click here to explore them.
Cuckoo Clock Competition
In order to let the iGEM Community grow together we started the Cuckoo Clock Cometition. This Lab-Fun-Photo-Contest intends to give an impression from the work of other Teams. Click to become impressed.
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