Team:Freiburg Bioware
From 2010.igem.org
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<h2>Project Results</h2> | <h2>Project Results</h2> | ||
<p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><h5>Heading:</h5></a> | <p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><h5>Heading:</h5></a> | ||
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<p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold"><h5>Head-Line:</h5></span></a> | <p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold"><h5>Head-Line:</h5></span></a> | ||
This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[Klick for more]</span></a></p> | This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[Klick for more]</span></a></p> | ||
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<a href="https://2010.igem.org/Team:Freiburg_Bioware/Project"><img src="https://static.igem.org/mediawiki/2010/5/5f/Freiburg10_Virus_Logo_Small.png" id="ccc" /> | <a href="https://2010.igem.org/Team:Freiburg_Bioware/Project"><img src="https://static.igem.org/mediawiki/2010/5/5f/Freiburg10_Virus_Logo_Small.png" id="ccc" /> | ||
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Revision as of 21:01, 9 October 2010
Gene delivery using viral vectors holds great promise for the treatment of acquired and inherited diseases. The human Adeno-Associated Virus (AAV) is a small, non-pathogenic, single-stranded DNA virus gaining increasing attention being both versatile and effective. Taking current knowledge into account, we generated a recombinant, modularized, BioBrick-compatible AAV ‘Virus Construction Kit’. We provide parts for modified capsid proteins, targeting modules, tumor-specific promoters, and prodrug-activating enzymes as well as readily assembled vectors for gene delivery and production of non-replicative virus particles. The viral tropism is altered by N-terminal fusion or by loop replacement of the capsid proteins. Functionality of viruses constructed from our kit was demonstrated by fluorescent protein expression in infected cells and by prodrug-induced killing of tumor cells upon viral delivery of a thymidine kinase. Incorporating multiple layers of safety, we provide a general tool to the growing field of personalized medicine and demonstrate its use in tumor therapy.
Project Results
Heading:
This Site is in Construction, later you will find more right here...[more]
Heading:
This Site is in Construction, later you will find more right here...[Klick for more]
Head-Line:
This Site is in Construction, later you will find more right here...[Klick for more]
Virus Construction Kit
Heading:
This Site is in Construction, later you will find more right here...[more]
Heading:
This Site is in Construction, later you will find more right here...[Klick for more]
Head-Line:
This Site is in Construction, later you will find more right here...[Klick for more]