Team:Freiburg Bioware/Project/Project Description

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The Experimental System

Therapy using viral vectors is an promising approach for

Modularization of the rAAV genome

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Modulatization of the RepCap plasmid

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Modulatization of the Vectorplasmid

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Modification of the viral surface in one cloning step - The ViralBrick standard

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Midifications of the Virus Shell via Loop Insertions

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Specific biotinylation of the Viral Schell - The Biotinylation Acceptor Peptide (BAP)

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Purification of Therapeutic Viral Vectors - The His-Affinity Tag

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Targeting of integrin overexpressing cells - The RGD Motif

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Arming the Viral Vector with therapeutic antibodies - The Z34C Motif

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Testing the limit for loop insertion - The Beta-Lactamase

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Method Development

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Arming: Killing the Tumor

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All-In-One: Testing multiple modified Viral Vectors

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Virus Construction Kit - The Manual

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