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Team:Freiburg Bioware/Project/Project Description
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The Experimental System
Therapy using viral vectors is an promising approach for
Modularization of the rAAV genome
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Modulatization of the RepCap plasmid
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Modulatization of the Vectorplasmid
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Modification of the viral surface in one cloning step - The ViralBrick standard
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Midifications of the Virus Shell via Loop Insertions
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Specific biotinylation of the Viral Schell - The Biotinylation Acceptor Peptide (BAP)
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Purification of Therapeutic Viral Vectors - The His-Affinity Tag
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Targeting of integrin overexpressing cells - The RGD Motif
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Arming the Viral Vector with therapeutic antibodies - The Z34C Motif
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Testing the limit for loop insertion - The Beta-Lactamase
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Method Development
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Arming: Killing the Tumor
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All-In-One: Testing multiple modified Viral Vectors
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Virus Construction Kit - The Manual
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