Team:Freiburg Bioware
From 2010.igem.org
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<!---Box on the upper right: BioBricks---> | <!---Box on the upper right: BioBricks---> | ||
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<a href="https://2010.igem.org/Team:Freiburg_Bioware/BioBricks"> | <a href="https://2010.igem.org/Team:Freiburg_Bioware/BioBricks"> | ||
<div><h2>BioBricks</h2> | <div><h2>BioBricks</h2> | ||
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<!---Box on the lower left: Biosafety---> | <!---Box on the lower left: Biosafety---> | ||
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<a href="https://2010.igem.org/Team:Freiburg_Bioware/Human_Practice/Biosafety"> | <a href="https://2010.igem.org/Team:Freiburg_Bioware/Human_Practice/Biosafety"> | ||
<h2>Biosafety</h2> | <h2>Biosafety</h2> | ||
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<!---Box on the lower right: Cuckoo Clock Competition---> | <!---Box on the lower right: Cuckoo Clock Competition---> | ||
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<a href="https://2010.igem.org/Team:Freiburg_Bioware/Team/Cuckoo Clock"> | <a href="https://2010.igem.org/Team:Freiburg_Bioware/Team/Cuckoo Clock"> | ||
<h2>Cuckoo Clock Competition</h2> | <h2>Cuckoo Clock Competition</h2> | ||
<img src="http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/4/40/Freiburg10_Cuckoo_Clock_Competition_button.png" id="ccc" /> | <img src="http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/4/40/Freiburg10_Cuckoo_Clock_Competition_button.png" id="ccc" /> | ||
<p class="standard">In order to let the iGEM Community grow together we started the Cuckoo Clock Cometition. This Lab-Fun-Photo-Contest intends to give an impression from the work of other Teams. Click to become impressed.</p> | <p class="standard">In order to let the iGEM Community grow together we started the Cuckoo Clock Cometition. This Lab-Fun-Photo-Contest intends to give an impression from the work of other Teams. Click to become impressed.</p> | ||
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+ | <!---Box on the lower right: Team---> | ||
+ | <div class="box_home_small"> | ||
+ | <a href="https://2010.igem.org/Team:Freiburg_Bioware/Team"> | ||
+ | <h2>Team</h2> | ||
+ | <img src="http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/4/40/Freiburg10_Cuckoo_Clock_Competition_button.png" id="ccc" /> | ||
+ | <p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold"><h5>Heading:</h5></span></a> | ||
+ | This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[Klick for more]</span></a></p> | ||
</a> | </a> | ||
</div><div class="clearfix"></div> | </div><div class="clearfix"></div> |
Revision as of 20:57, 9 October 2010
Gene delivery using viral vectors holds great promise for the treatment of acquired and inherited diseases. The human Adeno-Associated Virus (AAV) is a small, non-pathogenic, single-stranded DNA virus gaining increasing attention being both versatile and effective. Taking current knowledge into account, we generated a recombinant, modularized, BioBrick-compatible AAV ‘Virus Construction Kit’. We provide parts for modified capsid proteins, targeting modules, tumor-specific promoters, and prodrug-activating enzymes as well as readily assembled vectors for gene delivery and production of non-replicative virus particles. The viral tropism is altered by N-terminal fusion or by loop replacement of the capsid proteins. Functionality of viruses constructed from our kit was demonstrated by fluorescent protein expression in infected cells and by prodrug-induced killing of tumor cells upon viral delivery of a thymidine kinase. Incorporating multiple layers of safety, we provide a general tool to the growing field of personalized medicine and demonstrate its use in tumor therapy.
Project Results
Heading:
This Site is in Construction, later you will find more right here...[more]
Heading:
This Site is in Construction, later you will find more right here...[Klick for more]
Head-Line:
This Site is in Construction, later you will find more right here...[Klick for more]
Virus Construction Kit
Heading:
This Site is in Construction, later you will find more right here...[more]
Heading:
This Site is in Construction, later you will find more right here...[Klick for more]
Head-Line:
This Site is in Construction, later you will find more right here...[Klick for more]