Team:Freiburg Bioware
From 2010.igem.org
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- | <div class="virus"><img src="http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/8/87/Virus_homepage.gif" | + | <div class="virus"><img src="http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/8/87/Virus_homepage.gif" title="virus (3.5MB)" id="animated_virus"/></div> |
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<h2>Project Results</h2> | <h2>Project Results</h2> | ||
- | <p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><h5> | + | <p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><h5>Highlights: </h5></a> |
This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[more]</span></a></p> | This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[more]</span></a></p> | ||
<p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold"><h5>Heading:</h5></span></a> | <p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold"><h5>Heading:</h5></span></a> | ||
- | This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[Klick for more]</span></a></p> | + | This Site is in Construction, later on you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[Klick for more]</span></a></p> |
<p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold"><h5>Head-Line:</h5></span></a> | <p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold"><h5>Head-Line:</h5></span></a> | ||
This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[Klick for more]</span></a></p> | This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[Klick for more]</span></a></p> | ||
</div> | </div> | ||
- | <!---Big box on the left: Virus Construction Kit---> | + | <!---Big box on the left: Virus Construction Kit - Manual---> |
<div class="box_long"> | <div class="box_long"> | ||
<img class="right" src="http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/b/b2/Freiburg10_Manual-Logo.png" id="ccc" /> | <img class="right" src="http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/b/b2/Freiburg10_Manual-Logo.png" id="ccc" /> | ||
- | <h2>Virus Construction Kit</h2> | + | <h2>Virus Construction Kit - The Manual</h2> |
<p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><h5>Heading:</h5></a> | <p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><h5>Heading:</h5></a> | ||
This site is under construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[more]</span></a></p> | This site is under construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[more]</span></a></p> | ||
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This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[more]</span></a></p> | This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[more]</span></a></p> | ||
</div></li> | </div></li> | ||
- | <li><div class="news"> | + | <li><div class="news">This site is under construction!! </div></li> |
<li><div class="news"><img class="right" src="https://static.igem.org/mediawiki/2010/5/5f/Freiburg10_Virus_Logo_Small.png" id="ccc" /><p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><h5>Statistics:</h5></a> | <li><div class="news"><img class="right" src="https://static.igem.org/mediawiki/2010/5/5f/Freiburg10_Virus_Logo_Small.png" id="ccc" /><p><a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><h5>Statistics:</h5></a> | ||
This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[more]</span></a></p></div></li> | This Site is in Construction, later you will find more right here...<a href="https://2010.igem.org/Team:Freiburg_Bioware/Virus_Construction_Kit"><span class="bold">[more]</span></a></p></div></li> |
Revision as of 18:49, 20 October 2010
![virus (3.5MB)](http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/8/87/Virus_homepage.gif)
Gene delivery using viral vectors holds great promise for the treatment of acquired and inherited diseases. The human Adeno-Associated Virus (AAV) is a small, non-pathogenic, single-stranded DNA virus gaining increasing attention being both versatile and effective. Taking current knowledge into account, we generated a recombinant, modularized, BioBrick-compatible AAV ‘Virus Construction Kit’. We provide parts for modified capsid proteins, targeting modules, tumor-specific promoters, and prodrug-activating enzymes as well as readily assembled vectors for gene delivery and production of non-replicative virus particles. The viral tropism is altered by N-terminal fusion or by loop replacement of the capsid proteins. Functionality of viruses constructed from our kit was demonstrated by fluorescent protein expression in infected cells and by prodrug-induced killing of tumor cells upon viral delivery of a thymidine kinase. Incorporating multiple layers of safety, we provide a general tool to the growing field of personalized medicine and demonstrate its use in tumor therapy.
![](https://static.igem.org/mediawiki/2010/5/5f/Freiburg10_Virus_Logo_Small.png)
Project Results
Highlights:
This Site is in Construction, later you will find more right here...[more]
Heading:
This Site is in Construction, later on you will find more right here...[Klick for more]
Head-Line:
This Site is in Construction, later you will find more right here...[Klick for more]
![](http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/b/b2/Freiburg10_Manual-Logo.png)
Virus Construction Kit - The Manual
Heading:
This site is under construction, later you will find more right here...[more]
Statistics
- This site is under construction!!
Statistics:
This Site is in Construction, later you will find more right here...[more]
![](https://static.igem.org/mediawiki/2010/5/5f/Freiburg10_Virus_Logo_Small.png)
BioBricks
Modularisation and Modification of the viral tropismn and the effector function resulted in many different BioBricks.
Click here to explore them.
![](https://static.igem.org/mediawiki/2010/0/0d/Freiburg10_Danger_Virus.png)
Biosafety
The aspect of biological safety was considered well and a risk assessment and security profile for the Adeno-associated Virus were created. To hear about this click here.
![](http://www.molbiotech.uni-freiburg.de/iGEM/wiki2010/images/4/40/Freiburg10_Cuckoo_Clock_Competition_button.png)
Notebook
Head-Line:
This Site is in Construction, later you will find more right here...[Klick for more]
Sponsors
![Uni Freiburg](https://static.igem.org/mediawiki/2010/b/b8/Freiburg10_Uni-logo.jpg)
![Bioss](https://static.igem.org/mediawiki/2010/e/eb/Freiburg10_sponsors_bioss.jpg)
![kuk.lab](https://static.igem.org/mediawiki/2010/9/9d/Freiburg10_Sponsor_KuK-Lab.png)
![Roche](https://static.igem.org/mediawiki/2010/3/39/Freiburg10_sponsors_Roche.jpg)
![Qiagen](https://static.igem.org/mediawiki/2010/a/a5/Freiburg10_sponsors_Qiagen.jpg)
![Zeiss](https://static.igem.org/mediawiki/2010/7/7f/Freiburg10_Sponsor_Zeiss.jpg)
![Starlab](https://static.igem.org/mediawiki/2010/5/51/Freiburg10_Sponsor_StarLab.gif)
![agilent](https://static.igem.org/mediawiki/2010/f/f1/Freiburg10_Sponsor_Agilent.jpg)
![Fermentas](https://static.igem.org/mediawiki/2010/a/aa/Freiburg10_Sponsor_Fermentas.jpg)
![Hiss](https://static.igem.org/mediawiki/2010/8/89/Freiburg10_Sponsor_HiSS_Diagnostics.jpg)
![peqlab](https://static.igem.org/mediawiki/2010/6/65/Freiburg10_Sponsor_Peqlab.gif)
![Geneart](https://static.igem.org/mediawiki/2010/9/9a/Freiburg10_Sponsor_Geneart.png)
![Eppendorf](https://static.igem.org/mediawiki/2010/d/d2/Freiburg10_Sponsor_eppendorf.jpeg)
![Gilson](https://static.igem.org/mediawiki/2010/b/ba/Freiburg10_Sponsor_Gilson.jpeg)
![GATC](https://static.igem.org/mediawiki/2010/7/74/Freiburg10_Sponsor_GATC.jpg)
![ATG](https://static.igem.org/mediawiki/2010/f/fb/Freiburg10_Sponsor_ATG.jpg)
![Biozym](https://static.igem.org/mediawiki/2010/f/f4/Freiburg10_Sponsor_Biozym.png)
![Avidity](https://static.igem.org/mediawiki/2010/a/ad/Sponsor_Avidity.png)
![Mathworks](https://static.igem.org/mediawiki/2010/c/c3/Freiburg10_Sponsor_Mathworks.gif)