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</td>
<td>
It is believed that, epidermal growth factor (EGF) stimulates the growth of keratinocytes in vivo, and therefore plays an important role in the process of wound healing that depends on mitosis and migration of keratinocytes. Rhinewald and Green showed, in vitro that in the presence of growth factors, higher percentage of cells leave the resting state, enter and remain in the mitotic cycle. Assuming a similar effect of EGF on epidermal cells in vivo, the primary mechanism of enhanced wound healing is most likely due to increased proliferation of epidermal cells.
</td>
</tr>
</table>
</div>
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