===[http://partsregistry.org/wiki/index.php?title=Part:BBa_K364310 Ecdysone Receptor Ligand Binding Domain (D. Melanogaster)]===
===[http://partsregistry.org/wiki/index.php?title=Part:BBa_K364310 Ecdysone Receptor Ligand Binding Domain (D. Melanogaster)]===
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The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, which ultimately causes physiological changes that result in ecdysis (moulting). [http://partsregistry.org/wiki/index.php?title=Part:BBa_K364310 go to parts registry page for this part]
Our lipid detecting tool kit comprosis of 19 basic parts (11 ligand binding domains, 3 DNA binding domains and 5 other basic parts),9 composite chimeric receptors and 3 plasmid expression vectors and associated intermediates. Amongst our kit, parts of various speicies of the animalia kingdom may be found. The composite receptors are proof of concept that the basic parts acctually work. The bulk of the data (sequance, sub domains, 3d structure, ligand affinity and more..) can be found in the parts registry.
Ligand binding domains - Basic Parts
[http://partsregistry.org/wiki/index.php?title=Part:BBa_K364310 Ecdysone Receptor Ligand Binding Domain (D. Melanogaster)]
The ecdysone receptor is a nuclear receptor found in arthropods, where it controls development and contributes to other processes such as reproduction. The receptor is a non-covalent heterodimer of two proteins, the EcR protein and ultraspiracle protein (USP). It binds to and is activated by ecdysteroids. Pulses of 20-hydroxyecdysone occur during insect development, whereupon this hormone binds to the ecdysone receptor, a ligand-activated transcription factor found in the nuclei of insect cells. This in turn leads to the activation of many other genes, which ultimately causes physiological changes that result in ecdysis (moulting). [http://partsregistry.org/wiki/index.php?title=Part:BBa_K364310 go to parts registry page for this part]
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