Team:Peking

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==Human Practice==
==Human Practice==
<html><a href="https://2010.igem.org/Team:Peking/Humanpractice"><img src="https://static.igem.org/mediawiki/2010/2/29/HPFP.jpg" width=180 alt="Biosafety"  align="right"></a>
<html><a href="https://2010.igem.org/Team:Peking/Humanpractice"><img src="https://static.igem.org/mediawiki/2010/2/29/HPFP.jpg" width=180 alt="Biosafety"  align="right"></a>
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&nbsp;&nbsp;&nbsp;&nbsp;DNA recombination, Fragment synthesis, Bio-security... these are words that could hardly be ignored when doing researches of synthetic biology, which promises a great many improvements to our understanding of this world. The potential bio-security risk, however, is just around corner. <br>
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DNA recombination, Fragment synthesis, Bio-security... they are words that can hardly be passed by when doing researches of synthetic biology. When synthetic biology promises a great many improvements to our understanding of this world, the potential bio-security risk is just around corner. Gene horizontal transfer is something especially worth noting. In this summer, we did the research in these aspects, aiming to proactively find out the current situation in China, a beginner country for synthetic biology, and arouse people’s awareness on these issues.<br>
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&nbsp;&nbsp;&nbsp;&nbsp;Gene horizontal transfer, for example, is worth special attention. This summer, we did a thorough research on this topic, aiming at proactively finding out the current situation in China, a beginner in synthetic biology, and raised the awareness of researchers on such issues.<br>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="https://2010.igem.org/Team:Peking/Humanpractice"><font size=4>learn more</font></a>
&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<a href="https://2010.igem.org/Team:Peking/Humanpractice"><font size=4>learn more</font></a>
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Biosensor:
Based on reverse engineering principles, we engineered our bacteria into valid bioreporters for Hg(II) in aquatic environment. Rational design of genetic circuit topology was conducted to confer mercury sensor and regulator components high efficiency and robustness. Additionally, a new approach based on the use of multiple bioreporter cell lines to control assay variations and to improve in field application ease was also developed.

Expansion:   MerR family TFs share a high homology at
their metal binding domains, which implies that our strategies of bioreporter and bioabsorbent engineering might be applicable to other cases. Then our reverse engineering strategy was expanded to another common toxic heavy metal, lead (Pb) to prove the validness.

Application:       Traditional bioreporters are not practical when it
comes to in field application. One crucial factor is the preservation condition of the bacteria, often requiring costly instrument. We endeavo-
-red to solve this hard truth by development of a standard preservation method which endows our bioreporters with application ease.

Parts

    Our team submitted a library of thoroughly characterized and standardized parts. Therefore contributing an alternative set of tools towards heavy metal detection and decontamination in the iGEM context. What's more, as our MerR-family-derivated engineering method could be applicable in nearly all cases of heavy metal, our parts and corresponding documents provide a streamlined method for heavy metal bioreporter and bioabsorbent construction.

                                                          learn more

Team

    Eighteen students and three instructors are working on our project during this summer. We split up into several subgroups whose focus and results you can follow on the Notebook or Project pages. If you want to know more about the subgroups and the people involved, meet us on our Team page.


                                                                                                      learn more

Modeling

Modeling

Human Practice

Biosafety     DNA recombination, Fragment synthesis, Bio-security... these are words that could hardly be ignored when doing researches of synthetic biology, which promises a great many improvements to our understanding of this world. The potential bio-security risk, however, is just around corner.
    Gene horizontal transfer, for example, is worth special attention. This summer, we did a thorough research on this topic, aiming at proactively finding out the current situation in China, a beginner in synthetic biology, and raised the awareness of researchers on such issues.
                                                                learn more


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