Team:Tec-Monterrey/Instructors

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<h2>  Sponsors:</h2>
 
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<h1>Project Summary</h1>
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<h2>Dr. Mario Moisés Álvarez</h2>
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<img src="https://static.igem.org/mediawiki/2010/9/9b/Drmario.jpg" alt="Dr. Mario Álvarez" />
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Mario Moisés Álvarez is the former director of the Center for Biotechnology at Monterrey Institute of Technology and Higher Education (ITESM) in México. He is the coordinator of the Biotechnology Graduate Program at Monterrey Tech, and one of the youngest scientists in México ranked at high level by the Mexican System of Researchers, where he holds a Level 2 Researcher status. Dr. Álvarez has a Ph.D. from Rutgers University in Chemical and Biochemical Engineering, a Master on Science in Chemical Engineering from Rutgers University, another Master on Science in Process Engineering from ITESM, and a Bachelor Degree in Biochemistry from ITESM. He did a postdoctoral stay at Bristol Myers Squibb, at the Pharmaceutical Research Institute, working in different projects related to the design and scale-up of Pharmaceutical Processes, particularly reactive and crystallization processes.
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      Bacterial reporters or whole-cell bacterial sensors have always been an area of application for genetic manipulation and synthetic biology. As a matter of fact, constructing a bioreporter bacteria that has the ability to detect toxic chemicals is considered one of the first accomplishments in the discipline of synthetic biology <a href="#van">(van der Meer and Belkin, 2010)</a>. There are several advantages to using a bacterial bioreporter instead of a traditional physical or chemical sensors, for example, bacteria can offer the same specificity and sensitivity that traditional sensors offer, but they are much more portable and grow in inexpensive media. Furthermore, bacterial reporters also offer advantages over using other types of biosensors like enzymes and antibodies because they are living organisms and they are capable of analyzing samples through a process that involves many enzymes <a href="#yagi">(Yagi, 2007)</a>
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Dr. Álvarez main area of scientific expertise is laminar mixing (mixing operations at low speed or in high viscosity conditions). Currently, his group is working in the application of mixing knowledge on the design of bioreactors. These includes the design of novel high performance bioreactor systems for animal cell culture, the diagnosis of mixing performance in bioreactor by reactive methods, and the study of non-ideal mixing conditions in bioreactive systems.
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      The first bacterial reporters appeared 20 years ago <a href="#van">(van der Meer and Belkin, 2010)</a> although these early tests didn’t use genetically modified microorganisms. Further research and development in the areas of genetic engineering and synthetic biology have resulted in many more applications such as detection of contaminants <a href="#willardson">(Willardson, et. Al., 1998)</a> and sugar and amino acid availability in soils <a href="#jaeger">(Jaeger, et. Al., 1999)</a>. Even though the reporters have gotten more sophisticated and sensitive, we realized that there isn’t much mention of a single bacterial bioreporter capable of detecting different concentrations of a substance and reacting differently depending on the concentration.  
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      We thought the use of synthetic biology as well as the BioBrick standard could help create a “genetic circuit” <a href="#van">(van der Meer and Belkin, 2010)</a> capable of detecting different concentrations of a substance and reacting in a different manner depending on the amount detected. In our initial research we realized that the iGEM British Columbia 2009 team decided to do something similar, so we used parts of their project as a base and integrated parts of other previous iGEM projects in order to propose a new genetic construction capable of detecting different amounts of a certain substance. We call these new types of sensors, “intelligent biosensors”, because they have the ability to react in different ways depending on their surroundings.
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      With our project we hope to continue with the previous efforts of other iGEM teams, and at the same time propose a new type of genetic circuit for achieving these functions. In the process we plan to develop BioBricks for two new families of phage activators as well as different BioBrick constructons that can make our system easy to adapt, so that the creation of these “intelligent biosensors” becomes just a matter of choosing the substance of interest and choosing the different reporters.
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<h2><i>M. Sc</i> Sergio Ángel García Echauri</h2>
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<p class="blah"><a name="jaeger">Jaeger, C. H., et. Al. (June 1999)</a> Mapping of Sugar and Amino Acid Availability in Soil around Roots with Bacterial Sensors of Sucrose and Tryptophan. Applied and Environmental Microbiology, Vol. 65, No. 6, p. 2685 - 2690
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<a name="van">Van der Meer, J. R. and Belkin, S. (July 2010)</a> Where microbiology meets microengineering: design and applications of reporter bacteria. Nature Reviews Microbiology, Vol. 8, p. 511 - 522
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Sergio Ángel García Echauri is a current researcher at the Center for Biotechnology at Monterrey Institute of Technology and Higher Education (ITESM) in México, where he is developing his doctorate. His early formation was in the Autonomous University of Baja California, where he obtained his title as a Biologist. Later, he carried out a thesis on the Isolation and Identification of Psychrophillic Organisms from the Antarctica and Expression of a Superoxide Dismutase from <i>Deschampsia antarctica</i> in <i>Escherichia coli</i>.
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<a name="willardson">Willardson, B. M., et. Al. (March 1998)</a> Development and Testing of a Bacterial Biosensor for Toluene-Based Environmental Contaminants. Applied and Environmental Microbiology, Vol. 64, No. 3, p. 1006- 1012
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During the influenza outbreak in 2009, Sergio was part of the team that developed a novel technique for its detection and the creation of a recombinant vaccine against the A/H1N1 from cell culture.
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<a name="yagi">Yagi, K. (2007)</a> Applications of whole-cell bacterial sensors in biotechnology and environmental science. Applied Microbiology and Biotechnology, Vol. 73, p. 1251 - 1258
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Revision as of 19:54, 17 October 2010

Tec de Monterrey






























Dr. Mario Moisés Álvarez

Dr. Mario Álvarez Mario Moisés Álvarez is the former director of the Center for Biotechnology at Monterrey Institute of Technology and Higher Education (ITESM) in México. He is the coordinator of the Biotechnology Graduate Program at Monterrey Tech, and one of the youngest scientists in México ranked at high level by the Mexican System of Researchers, where he holds a Level 2 Researcher status. Dr. Álvarez has a Ph.D. from Rutgers University in Chemical and Biochemical Engineering, a Master on Science in Chemical Engineering from Rutgers University, another Master on Science in Process Engineering from ITESM, and a Bachelor Degree in Biochemistry from ITESM. He did a postdoctoral stay at Bristol Myers Squibb, at the Pharmaceutical Research Institute, working in different projects related to the design and scale-up of Pharmaceutical Processes, particularly reactive and crystallization processes.

Dr. Álvarez main area of scientific expertise is laminar mixing (mixing operations at low speed or in high viscosity conditions). Currently, his group is working in the application of mixing knowledge on the design of bioreactors. These includes the design of novel high performance bioreactor systems for animal cell culture, the diagnosis of mixing performance in bioreactor by reactive methods, and the study of non-ideal mixing conditions in bioreactive systems.

M. Sc Sergio Ángel García Echauri

M. Sc. Sergio García Sergio Ángel García Echauri is a current researcher at the Center for Biotechnology at Monterrey Institute of Technology and Higher Education (ITESM) in México, where he is developing his doctorate. His early formation was in the Autonomous University of Baja California, where he obtained his title as a Biologist. Later, he carried out a thesis on the Isolation and Identification of Psychrophillic Organisms from the Antarctica and Expression of a Superoxide Dismutase from Deschampsia antarctica in Escherichia coli.

During the influenza outbreak in 2009, Sergio was part of the team that developed a novel technique for its detection and the creation of a recombinant vaccine against the A/H1N1 from cell culture.

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