Team:Washington
From 2010.igem.org
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<img src="https://static.igem.org/mediawiki/2010/4/4b/Washington_testbanner.png" alt="21stCenturyAntibioticsBanner" usemap="#bannermap" /> | <img src="https://static.igem.org/mediawiki/2010/4/4b/Washington_testbanner.png" alt="21stCenturyAntibioticsBanner" usemap="#bannermap" /> | ||
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- | <area shape="rect" alt="START button" title="Explore the Wiki" coords=" | + | <area shape="rect" alt="START button" title="Explore the Wiki" coords="384,258,447,279" href="https://2010.igem.org/Team:Washington/Gram_Negative"/> |
- | + | <area shape="rect" alt="Player 1 Gram(-)" title="Gram(-) Therapeutic" coords="343,281,493,300" href="https://2010.igem.org/Team:Washington/Gram_Negative"/> | |
- | <area shape="rect" alt="" title=" | + | <area shape="rect" alt="Player 2 Gram(+)" title="Gram(+) Therapeutic" coords="343,302,492,320" href="https://2010.igem.org/Team:Washington/Gram_Positive"/> |
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- | + | ||
- | <area shape="poly" alt="Gram(+) | + | |
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<br> | <br> |
Revision as of 16:57, 27 October 2010
While vital to our quality of life, traditional antibiotics face the serious
problems of widespread bacterial resistance and destruction of natural gut
flora - problems which call for improved twenty-first century antibiotics.
Using synthetic biology tools, we designed, built, and tested two new
systems to fight infections by both broad types of bacteria - Gram-positive
and Gram-negative. Our first project targets Bacillus anthracis, the
Gram-positive pathogen that causes anthrax. We re-engineered an enzyme to
remove the pathogen's protective coating, rendering it defenseless against
the immune system. In our second project, we re-engineered and transplanted
a protein secretion system capable of combating Gram-negative bacteria into
E. coli. This system was designed to target Gram-negative pathogens in a
modular and controllable fashion. These two systems are the vanguard of a
new era of antibiotics using the power of nature harnessed with the tools of
synthetic biology.