Team:UCL London

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UCL IGEM 2010

RETURN TO IGEM 2010

  • Project Hypoxon aims to create cells capable of self-induction into the production phase, without the introduction of any chemical into the closed system. By exploiting genetically modified E.coli to respond to hypoxia, we eliminate the need of IPTG induction. A Green Fluorescent Protein would indicate that the product has theoretically been produced!

  • We are an interdisciplinary group of students and advisers. Click on the The Team to find out more. Also watch our video to find out what an exciting and fulfilling summer we've had!

  • Download free files to make your job easier.

  • Want to read the detailed reports of all the amazing events that we've participated in and organized, then click on the link below.
    iGEM Twitter

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    Download free files to make your job easier.

  • Want to know exactly what we've been doing on a daily basis and to find out how Project Hypoxon has progressed, visit our Notebook

  • We would like to thank all our sponsors for their contribution and support throughout this summer project. To find out more about who did what, follow this link.

Project Hypoxon

UCL’s Biochemical engineering department has been at the forefront of biopharmaceutical manufacture for years. Extraordinary advances in the life sciences have great potential to improve our quality of life through better medicines and a cleaner environment. Our project aims to create “independent” cells, capable of self-induction into the production phase, without the introduction of any chemical into the closed system. By exploiting genetically modified E.coli to respond to hypoxia, we eliminate the need of IPTG induction. The functioning genetic circuit would be signalled by the production of a fluorescent green dye. While the green dye can be used as a live monitoring technique for oxygen, replacing the green dye gene with pharmaceutical protein promises higher yields and more consistent batches which is a step closer to providing cheaper healthcare to everyone.

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