Team:Peking/Humanpractice

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==Introduction==
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&nbsp;&nbsp;&nbsp;&nbsp;The biosafety issue has been an everlasting topic for people to discuss about, and scientists emphasize special necessities in synthetic biology area. With the improvement of SB, there’re increasing projects and achievements in many countries all around the world to research the safety and ethical aspects of synthetic biology [1]. But no doubt that gene horizontal transfer, among all bio-safety issues, has proactively stimulated much more debates on these issues. As a developing country like China, the situation could be particularly different from those nations who enjoy high history on scientific research such as gene manipulations. A great many culture gaps can also lead to varies perspectives in terms of gene horizontal transfer. To investigate the domestic situation, we delivered questionnaires of biosafety based on international legislation; interviewed prominent Chinese scientists; tried to find out impressive phenomenon and conclusions through analysis and comparison. More importantly, we proposed some solutions and designs to eliminate the possible consequence of gene transfer. Last but not least, we made cooperation with Paris iGEM team in order to form specific guidelines on related issues, not only adapted our project to safer experiment procedures, but also aiming at contributing to an iGEM competition with more securities and less risks.</font></html>
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Development of synthetic biology are accelerating innovation across many research areas, from information processing to environmental monitoring, and from industrial productivity to breakthroughs in human health.[1] In the world of synthetic biology, scientists solve problems not merely depend on observation or analysis, but also the construction of biological systems and devices starting from DNA fragments and genetic circuits. [2]
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However, people believe that biological security risks arise when considering synthetic biology and DNA recombinant technology. Particularly, whether horizontal gene transfer (HGT), need more awareness and governance of manipulation has been a debate for years since 1970s. In the human practice of PKU iGEM team this year, we make the review as well as the investigation relevant to this topic, trying to answer following questions about HGT:
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1. Do most scientific researchers know what is HGT and how does it happen?
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2. Do we have effective solution to detect HGT?
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3. Can we efficiently eliminate the HGT and avoid potential risks?
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4. What measures and attitude should we take when facing these problems?
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Here, we review the studies of horizontal gene transfer and its current situation. Risks it might have, these hurdles and challenges currently represent would however be overcome by thorough realization and advances in science. Just like the saying goes, don’t throw out the baby along with the bath. We need thus to keep scientific researches on synthetic biology and its application activities moving on.
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==References:==
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[1] Hans Bügl ''et al. ''DNA synthesis and biological security. ''Nature Biotechnology ''25, 627 - 629 (2007)
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[2] Steven A. Benner & A. Michael Sismour. Synthetic biology. ''Nature Reviews Genetics'' 6, 533-543 (July 2005)
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==Reference==
 
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Revision as of 16:27, 26 October 2010

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   Human Practice Home

Overview


              *HGT Review
              *Proof of Concept
              *HGT Investigation
              *Acknowledgement

Introduction

Development of synthetic biology are accelerating innovation across many research areas, from information processing to environmental monitoring, and from industrial productivity to breakthroughs in human health.[1] In the world of synthetic biology, scientists solve problems not merely depend on observation or analysis, but also the construction of biological systems and devices starting from DNA fragments and genetic circuits. [2]


However, people believe that biological security risks arise when considering synthetic biology and DNA recombinant technology. Particularly, whether horizontal gene transfer (HGT), need more awareness and governance of manipulation has been a debate for years since 1970s. In the human practice of PKU iGEM team this year, we make the review as well as the investigation relevant to this topic, trying to answer following questions about HGT:

1. Do most scientific researchers know what is HGT and how does it happen?

2. Do we have effective solution to detect HGT?

3. Can we efficiently eliminate the HGT and avoid potential risks?

4. What measures and attitude should we take when facing these problems?


Here, we review the studies of horizontal gene transfer and its current situation. Risks it might have, these hurdles and challenges currently represent would however be overcome by thorough realization and advances in science. Just like the saying goes, don’t throw out the baby along with the bath. We need thus to keep scientific researches on synthetic biology and its application activities moving on.


References:

[1] Hans Bügl et al. DNA synthesis and biological security. Nature Biotechnology 25, 627 - 629 (2007) [2] Steven A. Benner & A. Michael Sismour. Synthetic biology. Nature Reviews Genetics 6, 533-543 (July 2005)



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