Team:Imperial College London/Modelling/Signalling
From 2010.igem.org
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We are assuming an initial concentration of Phosphate and ComE of 100nM. | We are assuming an initial concentration of Phosphate and ComE of 100nM. | ||
If we change either [AIP]<html><sub>0</sub></html> or [ComE]<html><sub>0</sub></html>, then the final concentration of ComE* will always tend towards <html>5×10<sup>-11</sup>M</html>. <html>[ComE*]<sub>final</sub></html> will always tend towards this value, unless the initial concentrations of Phosphate and ComE are changed. However, if we increase both [AIP]<html><sub>0</sub></html> and [ComE]<html><sub>0</sub></html> at the same time, then [ComE*]<html><sub>final</sub></html> will be reached much faster (i.e. slope increases). | If we change either [AIP]<html><sub>0</sub></html> or [ComE]<html><sub>0</sub></html>, then the final concentration of ComE* will always tend towards <html>5×10<sup>-11</sup>M</html>. <html>[ComE*]<sub>final</sub></html> will always tend towards this value, unless the initial concentrations of Phosphate and ComE are changed. However, if we increase both [AIP]<html><sub>0</sub></html> and [ComE]<html><sub>0</sub></html> at the same time, then [ComE*]<html><sub>final</sub></html> will be reached much faster (i.e. slope increases). | ||
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+ | <div ALIGN=CENTER> | ||
+ | {| style="background:#e7e7e7;text-align:center;font-family: helvetica, arial, sans-serif;color:#555555;margin- top:5px;padding: 2px;" cellspacing="5"; | ||
+ | |- | ||
+ | |[[Image:IC_Signalling_Results1.png|450px]] | ||
+ | |- | ||
+ | |Graph showing how [ComE]<html><sub>final</sub> eventually reaches the value 5×10<sup>-11</sup>M</html>. | ||
+ | |} | ||
+ | </div> | ||
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|<html><h2>Download Matlab files</h2></html> | |<html><h2>Download Matlab files</h2></html> |
Revision as of 17:59, 25 October 2010
Modelling | Overview | Detection Model | Signaling Model | Fast Response Model | Interactions |
A major part of the project consisted of modelling each module. This enabled us to decide which ideas we should implement. Look at the Fast Response page for a great example of how modelling has made a major impact on our design! |