Team:Cambridge/turingpatterns

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(Papers on Turing patterns)
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* Planned to use similar quorum sensing mechanisms with the lux operon to detect activity. However, the lux operon would not work in a gram positive organism such as Bacillus therefore only E.coli could work.
* Planned to use similar quorum sensing mechanisms with the lux operon to detect activity. However, the lux operon would not work in a gram positive organism such as Bacillus therefore only E.coli could work.
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==Papers on Turing patterns==
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==Own Research==
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Papers on Turing Patterns
* Original paper from Alan Turing: http://www.dna.caltech.edu/courses/cs191/paperscs191/turing.pdf
* Original paper from Alan Turing: http://www.dna.caltech.edu/courses/cs191/paperscs191/turing.pdf
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Further information
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*Different signalling mechanisms have a large amount of cross-talk in bacteria
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*The ACL Transcription factor is very specific initially but when bound becomes very non-specific, therefore cannot use two distinct systems in the same bacteria expressing different outputs in the same bacteria, instead 2 different strains would have to be used. This was the reason why a predator-prey model worked in a previous study.
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* In the proposed system, there would be an activator and an inhibitor, with different diffusion rates due to the chain length of the molecules. The activator would be a short chain molecule and the inhibitor a long chain molecule so that the inhibitor diffuses slowly.
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*One suggestion is that metabolites could be used as the morphogens in this system, for example metabolites that release or free another signalling molecule from the media, e.g. Arabinose - http://en.wikipedia.org/wiki/Arabinose. 
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* Another suggestion was peptide signalling, which uses an AGR-like system. There are 4 proteins, a pre-peptide, a processing, secreting and supporting peptide, and 2 sensing peptides.
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Advantages of the Turing Project
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* A new quorum sensing molecular system could be added to the registry which if a proven system could be easily applied to other systems. This would stand alone as an achievement no matter what the other successes or failures.
==Conclusion==
==Conclusion==

Revision as of 15:07, 15 July 2010