Team:Peking

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       Biosensor:
       Based on reverse engineering principles, we
   engineered our bacteria into valid bioreporters
   for Hg(II) in aquatic environment. Rational desi-
   -gn of genetic circuit topology was conducted to
   confer mercury sensor and regulator compone-
   -nts high efficiency and robustness. Additionally,
    a new approach based on the use of multiple
   bioreporter cell lines to control assay variations
   and to improve in field application ease was also
   developed.
                                           learn more


       Expansion:    MerR family TFs share a high homology at their
   metal binding domains, which implies that our strategies of bioreporter
   and bioabsorbent engineering might be applicable to other cases. Then our
    reverse engineering strategy was expanded to another common toxic heavy
    metal, lead (Pb) to prove the validness of our engineering strategy.learn more

Parts

    Our team submitted a library of thoroughly characterized and standardized parts. Therefore contributing an alternative set of tools towards heavy metal detection and decontamination in the iGEM context. What's more, as our MerR-family-derivated engineering method could be applicable in nearly all cases of heavy metal, our parts and corresponding documents provide a streamlined method for heavy metal bioreporter and bioabsorbent construction.

                                                          learn more

Team

    Eighteen students and three instructors are working on our project during this summer. We split up into several subgroups whose focus and results you can follow on the Notebook or Project pages. If you want to know more about the subgroups and the people involved, meet us on our Team page.


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