Team:Washington
From 2010.igem.org
(→Antibiotics for the 21st Century) |
(→Antibiotics for the 21st Century) |
||
Line 67: | Line 67: | ||
<div style="text-align:right"> | <div style="text-align:right"> | ||
- | '''[[Team:Washington/Project/Mougous]] →''' | + | '''[[Team:Washington/Project/Mougous|Gram(-) Therapeutic]] →''' |
</div> | </div> | ||
{{Template:Team:Washington/Templates/Footer}} | {{Template:Team:Washington/Templates/Footer}} |
Revision as of 22:07, 22 September 2010
Antibiotics for the 21st Century
While vital to our quality of life, traditional antibiotics face the serious problems of widespread bacterial resistance and destruction of natural gut flora - problems which call for improved twenty-first century antibiotics. Using synthetic biology tools, we designed, built, and tested two new systems to fight infections by both broad types of bacteria - Gram-positive and Gram-negative. Our first project targets Bacillus anthracis, the Gram-positive pathogen that causes anthrax. We re-engineered an enzyme to remove the pathogen's protective coating, rendering it defenseless against the immune system. In our second project, we re-engineered and transplanted a protein secretion system capable of combating Gram-negative bacteria into E. coli. This system was designed to target Gram-negative pathogens in a modular and controllable fashion. These two systems are the vanguard of a new era of antibiotics using the power of nature harnessed with the tools of synthetic biology.
Things to Do:
- more pictures everywhere!
- main graphic
- abstract
- front page
- pic of secretion apparatus
- gram(+) therapeutic
- design
- foldit pictures
- captions
- explain foldit
- test results
- more descriptive images
- design