Team:Washington

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<img id="mainimg" src="/wiki/images/4/41/Main_graphic.png" alt="A Graphical Overview Will Go Here" />
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<img src="https://static.igem.org/mediawiki/2010/b/be/Uwb.gif" alt="21stCenturyAntibioticsBanner" usemap="#bannermap" />
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<area shape="rect" alt="START button" title="Explore the Wiki" coords="384,258,447,279" href="https://2010.igem.org/Team:Washington/Gram_Negative"/>
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<area shape="rect" alt="Player 1 Gram(-)" title="Gram(-) Therapeutic" coords="343,281,493,300" href="https://2010.igem.org/Team:Washington/Gram_Negative"/>
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<area shape="rect" alt="Player 2 Gram(+)" title="Gram(+) Therapeutic" coords="343,302,492,320" href="https://2010.igem.org/Team:Washington/Gram_Positive"/>
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<area shape="poly" alt="Gram(+) Side" title="Gram(+) Therapeutic" coords="329,269,326,319,279,350,5,349,5,6,165,6,146,88,165,99,170,131,139,164,140,197,174,211" href="https://2010.igem.org/Team:Washington/Gram_Positive"/>
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<!---------------------------------------PAGE CONTENT GOES BELOW THIS---------------------------------------->
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While vital to our quality of life, traditional antibiotics face the serious
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problems of widespread bacterial resistance and destruction of natural gut
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flora - problems which call for improved twenty-first century antibiotics.
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Using synthetic biology tools, we designed, built, and tested two new
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systems to fight infections by both broad types of bacteria - Gram-positive
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and Gram-negative.  Our first project targets ''Bacillus anthracis'', the
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Gram-positive pathogen that causes anthrax.  We re-engineered an enzyme to
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remove the pathogen's protective coating, rendering it defenseless against
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the immune system.  In our second project, we re-engineered and transplanted
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a protein secretion system capable of combating Gram-negative bacteria into
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''E. coli''.  This system was designed to target Gram-negative pathogens in a
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modular and controllable fashion.  These two systems are the vanguard of a
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new era of antibiotics using the power of nature harnessed with the tools of
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synthetic biology.
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=== 21st Century Antibiotics ===
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'''[[Team:Washington/Gram_Negative|Gram(-) Therapeutic]]'''
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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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'''[[Team:Washington/Gram_Positive|Gram(+) Therapeutic]]'''
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baker group designed a protein therapeutic computationally, mougous rationally designed a probiotic…
 
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Latest revision as of 01:14, 28 October 2010

21stCenturyAntibioticsBanner START button Player 1 Gram(-) Player 2 Gram(+) Gram(+) Side Gram(-) Side


While vital to our quality of life, traditional antibiotics face the serious problems of widespread bacterial resistance and destruction of natural gut flora - problems which call for improved twenty-first century antibiotics. Using synthetic biology tools, we designed, built, and tested two new systems to fight infections by both broad types of bacteria - Gram-positive and Gram-negative. Our first project targets Bacillus anthracis, the Gram-positive pathogen that causes anthrax. We re-engineered an enzyme to remove the pathogen's protective coating, rendering it defenseless against the immune system. In our second project, we re-engineered and transplanted a protein secretion system capable of combating Gram-negative bacteria into E. coli. This system was designed to target Gram-negative pathogens in a modular and controllable fashion. These two systems are the vanguard of a new era of antibiotics using the power of nature harnessed with the tools of synthetic biology.


Gram(-) Therapeutic                  Gram(+) Therapeutic


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