"
Team:Warsaw/Stage1/Modeling
From 2010.igem.org
(Difference between revisions)
| Line 12: | Line 12: | ||
<div class="note"> Available software</div> | <div class="note"> Available software</div> | ||
| - | <p>People used to design computational programs that would automaticall locate bacterialribosome binding sittes, various techniques were used[] including neural networks[]. However the software was capable only of finding the sequence and didn't give any information about the strength of RBS. In 2009 Nature issue the revolutionary software has been described[]. RBS calculator allows prediction of RBS strength, | + | <br><p>People used to design computational programs that would automaticall locate bacterialribosome binding sittes, various techniques were used[] including neural networks[]. However the software was capable only of finding the sequence and didn't give any information about the strength of RBS. In 2009 Nature issue the revolutionary software has been described[]. RBS calculator allows prediction of RBS strength, |
moreover it designs RBS of desired strength for specific gene sequence. In 2010 another RBS strength predictor was created[]. | moreover it designs RBS of desired strength for specific gene sequence. In 2010 another RBS strength predictor was created[]. | ||
| - | + | <br> | |
<div class="note">Mathematics behind modeling</div> | <div class="note">Mathematics behind modeling</div> | ||
| - | + | A mathematical mofdel for transcription initiation has been clearly describrd by ___ in 2010. Upon similare models are based the current predictors. Model contains lots of mathematics but it is based on biological common sense: <br>We all know that for transcription initiation the ribosome has to be recruted to the RNA. | |
| + | <br> First there must be accesible RNA molecue | ||
| + | <br> Then the ribosome must | ||
| + | <br> | ||
| + | The | ||
| + | <br> | ||
<div class="note">Results</div> | <div class="note">Results</div> | ||
</p> | </p> | ||
Revision as of 20:39, 26 October 2010
Modeling
Available software
People used to design computational programs that would automaticall locate bacterialribosome binding sittes, various techniques were used[] including neural networks[]. However the software was capable only of finding the sequence and didn't give any information about the strength of RBS. In 2009 Nature issue the revolutionary software has been described[]. RBS calculator allows prediction of RBS strength,
moreover it designs RBS of desired strength for specific gene sequence. In 2010 another RBS strength predictor was created[].
Mathematics behind modeling
A mathematical mofdel for transcription initiation has been clearly describrd by ___ in 2010. Upon similare models are based the current predictors. Model contains lots of mathematics but it is based on biological common sense: We all know that for transcription initiation the ribosome has to be recruted to the RNA.
First there must be accesible RNA molecue
Then the ribosome must
The
Results
Fig 1.
Fig 2.
