Team:SDU-Denmark/project-bc

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(Difference between revisions)
(Model results)
(Description of the model)
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When light hits the photo receptor SRII, the signal is transduced through the HtrII and Tsr and on to the enzyme CheW. CheW is then activated because it is a straight-forward signal transduction. The proteins SRII and HtrII are not considered in the model and the equation for the activation of CheW is:
When light hits the photo receptor SRII, the signal is transduced through the HtrII and Tsr and on to the enzyme CheW. CheW is then activated because it is a straight-forward signal transduction. The proteins SRII and HtrII are not considered in the model and the equation for the activation of CheW is:
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[[Image:Team-SDU-Denmark-Flow.gif|center]]
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[[Image:Team-SDU-Denmark-Chewa.png|center]]
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When the CheW enzyme is activated, it induces auto-phosphorylation of CheA. The phosphorylated CheA can then phosphorylate the enzymes CheY and CheB. The equation for CheA-p concentration is given by:  
When the CheW enzyme is activated, it induces auto-phosphorylation of CheA. The phosphorylated CheA can then phosphorylate the enzymes CheY and CheB. The equation for CheA-p concentration is given by:  
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[[Image:Team-SDU-Denmark-Flow.gif|center]]
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[[Image:Team-SDU-Denmark-CheAp.png|center]]
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Phosphorylated CheY is produced by phosphorylation of CheA and is removed by CheZ which, in this model, is defined by a constant k. This can be described mathematically by this equation:
Phosphorylated CheY is produced by phosphorylation of CheA and is removed by CheZ which, in this model, is defined by a constant k. This can be described mathematically by this equation:
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[[Image:Team-SDU-Denmark-Flow.gif|center]]
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[[Image:Team-SDU-Denmark-CheYp.png|center]]
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Phosphorylated CheB is dephosphorylated when methylated Tsr is demethylated, this can be described mathematically by this equation:
Phosphorylated CheB is dephosphorylated when methylated Tsr is demethylated, this can be described mathematically by this equation:
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[[Image:Team-SDU-Denmark-Flow.gif|center]]
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[[Image:Team-SDU-Denmark-CheBp.png|center]]
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Methylated Tsr is constantly produced by the CheR enzyme which, in this model, is also considered a constant. The demethylation is performed by CheB-p. The concentration of methylated Tsr can be described by this equation:
Methylated Tsr is constantly produced by the CheR enzyme which, in this model, is also considered a constant. The demethylation is performed by CheB-p. The concentration of methylated Tsr can be described by this equation:
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[[Image:Team-SDU-Denmark-Flow.gif|center]]
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[[Image:Team-SDU-Denmark-TSRm.png|center]]
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In Berkeley Madonna it is possible to define different parameters as sliders which enable the user to change parameters continually while the model is running. The sliders used in the model are:
In Berkeley Madonna it is possible to define different parameters as sliders which enable the user to change parameters continually while the model is running. The sliders used in the model are:

Revision as of 20:44, 26 October 2010