Team:Warsaw/Stage1/Modeling

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• Team
• Attribution
• Sponsors
• Acknowledgemets

• Idea
• Background
• Promoters Measured
• RBSes Measured
• ExpressIt! Vectors
• Modeling

• Idea
• Background
• Design
• Results

• Idea
• Background and Design
• Results
• Gallery of microphotographs

• Idea
• Background
• Design
• Results
• Modeling

• Parts
• Labbook

• Licensing of biological parts
• Syntetic biology in Poland
• Synthetic BioLectures gallery
• iGEM survey

• About Biobrick Manager
• See Biobrick Manager

Modeling

People used to design computational programs that would automaticall locate bacterialribosome binding sittes, various techniques were used[] including neural networks[]. However the software was capable only of finding the sequence and didn't give any information about the strength of RBS. In 2009 Nature issue the revolutionary software has been described[]. RBS calculator allows prediction of RBS strength, moreover it designs RBS of desired strength for specific gene sequence. In 2010 another RBS strength predictor was created[].

A mathematical mofdel for transcription initiation has been clearly describrd by ___ in 2010. Upon similare models are based the current predictors. Model contains lots of mathematics but it is based on biological common sense:
We all know that for transcription initiation the ribosome has to be recruted to the RNA.
First there must be accesible RNA molecue
Then the ribosome must
The

Fig 1. Fig 2.