| Detailed Description
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| We are assuming steady-state for AIP, Phosphate, ComD and ComE in our cell/in the solution. Hence, we can neglect production and degradation rates of ComD and ComE.
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| Overview of the signalling module
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| Equation 1: AIP binds to ComD receptor to form a complex (AIP-ComD)
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| AIP + ComD ↔ AIP-ComD
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| Graph showing production of AIP-ComD
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| Equation 2: Phosphate binds to the AIP-ComD complex to form another complex (AIP-ComD*)
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| AIP-ComD + Phosphate ↔ AIP-ComD*
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| Graph showing production of AIP-ComD*
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| Equation 3: ComE binds to the AIP-ComD* recepetor to form another complex (AIP-ComD*-ComE)
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| AIP-ComD* + ComE ↔ AIP-ComD*-ComE
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| Graph showing production of AIP-ComD*-ComE
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| Equation 4: Phosphate group on ComD binds to ComE and forms two products: phosphorylated ComE (ComE*) and AIP-ComD
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| AIP-ComD*-ComE ↔ AIP-ComD + ComE*
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| Graph showing production of ComE*
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| Using the Law of Mass Action, we can rewrite these 4 equations:
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| In the above equations, the forwards reaction constants are represented by k1,2,3,4, for the first, second, third and fourth reaction, respectively. The backwards reaction constants are represented by k-1,-2,-3,-4.
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| Click here for the results of this model...
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