Modeling

For the modeling part we considered the three main parts:

• the virus production
• the infection of a target cell
• the therapy

For the first two models we assumed reactions according to the law of mass action to create a model of ordinary differential equations (ODE).

Model for Virus Production

Reaction Scheme

The reaction scheme for the virus production is considered as follows:
In the extracellular medium is a starting concentration of the four principle plasmids - the plasmid coding for the helper proteins (helper), the gene of interest (goi) and two types of DNA coding for the capsid proteins (capwt [wild type], capmod [modified]).

Reduced Reaction Scheme

Differential Equations

Model for Virus Infection

Reaction Scheme

Reduced Reaction Scheme

Differential Equations