Team:MIT mammalian Circuit

From 2010.igem.org

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Our project began with idea of a biological touchscreen. We envisioned a cellular 'iPad', a plate of cells that could sense applied pressure and differentiate in response. There are a ton of applications for this technology; at the most basic level, one could imagine drawing a pattern onto a cellular monolayer and watch bone form around the outline. The system could also be used to study morphogenesis, to explore the role of chemical and mechanical signaling in differentiation by trying to build analogous synthetic counterparts. The cellular differentiation toolkit developed in this project could potentially help create a construct a morphogenetic system from scratch. We've developed a basic standard for linking mechanical sensing to cellular differentiation; we built the groundwork for a complex tissue differentiation system, and hope to see it devevlop to support even more intricate systems.  
Our project began with idea of a biological touchscreen. We envisioned a cellular 'iPad', a plate of cells that could sense applied pressure and differentiate in response. There are a ton of applications for this technology; at the most basic level, one could imagine drawing a pattern onto a cellular monolayer and watch bone form around the outline. The system could also be used to study morphogenesis, to explore the role of chemical and mechanical signaling in differentiation by trying to build analogous synthetic counterparts. The cellular differentiation toolkit developed in this project could potentially help create a construct a morphogenetic system from scratch. We've developed a basic standard for linking mechanical sensing to cellular differentiation; we built the groundwork for a complex tissue differentiation system, and hope to see it devevlop to support even more intricate systems.  
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<b> &nbsp;&nbsp;Mechanical Signaling &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Circuit Design &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  Bone Differentiation </b>
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<b>Click on the panels below to go to the experimental pages</b>
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<b> &nbsp;&nbsp;Mechanical Signaling &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Circuit Design &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;  Bone Differentiation </b>
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<a href="https://2010.igem.org/Team:MIT_mammalian_Mechanosensation" target="_blank"> <img width=230px src="https://static.igem.org/mediawiki/2010/7/76/Mechanosensitive_Promoter_Button.jpg"> </a>
<a href="https://2010.igem.org/Team:MIT_mammalian_Mechanosensation" target="_blank"> <img width=230px src="https://static.igem.org/mediawiki/2010/7/76/Mechanosensitive_Promoter_Button.jpg"> </a>

Revision as of 05:05, 26 October 2010

The Cellular Touchpad
Our project began with idea of a biological touchscreen. We envisioned a cellular 'iPad', a plate of cells that could sense applied pressure and differentiate in response. There are a ton of applications for this technology; at the most basic level, one could imagine drawing a pattern onto a cellular monolayer and watch bone form around the outline. The system could also be used to study morphogenesis, to explore the role of chemical and mechanical signaling in differentiation by trying to build analogous synthetic counterparts. The cellular differentiation toolkit developed in this project could potentially help create a construct a morphogenetic system from scratch. We've developed a basic standard for linking mechanical sensing to cellular differentiation; we built the groundwork for a complex tissue differentiation system, and hope to see it devevlop to support even more intricate systems.

Click on the panels below to go to the experimental pages

  Mechanical Signaling                     Circuit Design                      Bone Differentiation

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