Team:MIT mammalian Switch
From 2010.igem.org
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<br>1. Hef1a promoter leads to low level, constitutive expression of the two halves (VgEcR and RxR) of a receptor responsive to the chemical ponasterone A (PonS). | <br>1. Hef1a promoter leads to low level, constitutive expression of the two halves (VgEcR and RxR) of a receptor responsive to the chemical ponasterone A (PonS). | ||
<br>2. VgEcR, RxR, and PonS combine to form an active complex. | <br>2. VgEcR, RxR, and PonS combine to form an active complex. |
Revision as of 10:12, 27 October 2010
Synthetic Switch: Implementation of Bistable Toggles in Mammalian Cells |
It is useful for a synthetic system capable of sensing mechanical stimuli to be able to convert a transient signal into a constitutive response. During the summer we designed both a complete and a simplified bistable toggle with a low and high output state using positive feedback loops.
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