Team:Chiba/Safety

From 2010.igem.org

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Revision as of 08:39, 27 October 2010

Safety issue

We’re inspired by double-click of computer’s mouse.
It doesn’t react by first input but react by second input. So we designed bacterial DNA sequence which works like it. Furthermore, we built time-limit in genetic sequence between the first and the second input like a computer mouse. Bacteria which have the DNA sequence can distinguish between the first input and the second one. Once in a while, bacteria might receive input which wasn’t intended. But it was the first input so bacteria don’t react. Even if there was input not intended, bacteria don’t react unless the second input is entered. Moreover, when the limit-time which controlled by the genetic system is passed, the system is going to return to the initial state. So we expect this DNA sequence will work as a safety device.

Would any of your project ideas raise safety issues in terms of:
- researcher safety,
- public safety, or
- environmental safety?
- Our theme is double click system in bacteria and we expect that it will be used for eliminating false input.
  It can raise accuracy of work to the target and reduce side effect by responding double click.
  We hope this system to be used for safety device on labs.

Do any of the new BioBrick parts (or devices) that you made this year raise any safety issues? If yes,
- did you document these issues in the Registry?
- how did you manage to handle the safety issue?
- How could other teams learn from your experience?
- We've desinged pulse generator and some hybrid promoters. We've also registed the parts.
  We think construction of these parts can be used as safety device.
  For example, hybrid promoter is low unregulated and repression for the promoter is stronger than activation for.
  So, expression of DNA occurs in specific environment which can mean safety device.
  If reaction needs the protein expressed by pulse, the pulse also can be safety device.
  Because, reaction must be done in fixed time whose the protein exists in.

Is there a local biosafety group, committee, or review board at your institution?
- If yes, what does your local biosafety group think about your project?
- If no, which specific biosafety rules or guidelines do you have to consider in your country?

Do you have any other ideas how to deal with safety issues that could be useful for future iGEM competitions? How could parts, devices and systems be made even safer through biosafety engineering?

Go to safety page.

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-<p><strong>Key questions </strong></p>
+<table border="0" cellpadding="30" cellspacing="0">
-<p>For iGEM 2010 teams are asked to detail how they approached any issues of biological safety associated with their projects. Specifically, teams should consider the following questions: </p>
+<tr>
-</div>
+  <td width="600px"><font size="5" face=verdana>Safety issue</font><br>
+  <hr width="500" size="1" align="left"><br>
+  <font size="2" face=verdana>
+We’re inspired by double-click of computer’s mouse.<br>
+It doesn’t react by first input but react by second input. So we designed bacterial DNA sequence which works like it. Furthermore, we built time-limit in genetic sequence between the first and the second input like a computer mouse. Bacteria which have the DNA sequence can distinguish between the first input and the second one. Once in a while, bacteria might receive input which wasn’t intended. But it was the first input so bacteria don’t react. Even if there was input not intended, bacteria don’t react unless the second input is entered. Moreover, when the limit-time which controlled by the genetic system is passed, the system is going to return to the initial state. So we expect this DNA sequence will work as a safety device.
+</font></td>
+<td width="200px"><img src="https://static.igem.org/mediawiki/2010/7/7c/Click.jpg" width="300px">
+</td>
+</tr>
+</table>