Team:British Columbia

From 2010.igem.org

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Revision as of 10:24, 20 July 2010

This is a template page. READ THESE INSTRUCTIONS.

You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples HERE.

You MUST have a team description page, a project abstract, a complete project description, a lab notebook, and a safety page. PLEASE keep all of your pages within your teams namespace.

You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.

File:British Columbia logo.png

200px

Project Description

With the aim of dispersing Staphylococcus aureus biofilms, the 2010 UBC iGEM Team is working to express an endogenous bacteriophage and biofilm matrix-degrading enzyme DspB under the control of the Agr quorum-sensing system. We will be using existing BioBrick parts (the P2 promoter and AgrCA genes) as well as creating our own DspB Biobrick part. In addition, we plan to develop a new standard for working with bacteriophages that are 15-50kbp in length.

Our team is composed of 9 undergradate students, 2 graduate advisors and 3 faculty advisors. We are a diverse team from various disciplines including Pharmacology, Life Sciences, Physiology, Chemical and Biological Engineering, Materials Engineering, Engineering Physics and Computer Science.

Our project will include all 3 components of an iGEM endeavor.

The core of our project will be the design and engineering of a bacteriophage that disintegrates a S. aureus biofilm under the control of quorum sensing molecules. The quorum sensing will control when the phage switches from a lysogenic to lytic. The matrix-degrading enzyme will be part of the phage genome, putting it under the control of quorum sensing as well.

The modeling component will produce a model that describes the population dynamics of the engineered bacteriophage and the affected biofilm. Simulations of our model will be implemented in MATLAB. The goals of the model are threefold: 1) Write a functional math model of the system, 2) Provide numerical simulations that may predict the outcome of the system 3) Use what we learn from making the model to make hypotheses that we can test with our system.

The human practices project will be a compilation of creative works from each of our team members that addresses different issues and problems and conveys thoughts and ideas regarding the diverse aspects of synthetic biology and genetic engineering. This component will encourage thinking about modern biotechnology from different perspectives and promote the synthesis of viewpoints and notions of people from a broad range of backgrounds and disciplines.

File:British Columbia team.png

Your team picture

Team Example

Home	Team	Official Team Profile	Project	Parts Submitted to the Registry	Modeling	Notebook	Safety

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-''Tell us more about your project.  Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
+<h2>Project Description</h2>
+With the aim of dispersing Staphylococcus aureus biofilms, the 2010 UBC iGEM Team is working to express an endogenous bacteriophage and biofilm matrix-degrading enzyme DspB under the control of the Agr quorum-sensing system. We will be using existing BioBrick parts (the P2 promoter and AgrCA genes) as well as creating our own DspB Biobrick part. In addition, we plan to develop a new standard for working with bacteriophages that are 15-50kbp in length.
+Our team is composed of 9 undergradate students, 2 graduate advisors and 3 faculty advisors.  We are a diverse team from various disciplines including Pharmacology, Life Sciences, Physiology, Chemical and Biological Engineering, Materials Engineering, Engineering Physics and Computer Science.
+Our project will include all 3 components of an iGEM endeavor.
+The core of our project will be the design and engineering of a bacteriophage that disintegrates a S. aureus biofilm under the control of quorum sensing molecules. The quorum sensing will control when the phage switches from a lysogenic to lytic.  The matrix-degrading enzyme will be part of the phage genome, putting it under the control of quorum sensing as well.
+The modeling component will produce a model that describes the population dynamics of the engineered bacteriophage and the affected biofilm. Simulations of our model will be implemented in MATLAB. The goals of the model are threefold: 1) Write a functional math model of the system, 2) Provide numerical simulations that may predict the outcome of the system  3) Use what we learn from making the model to make hypotheses that we can test with our system.
+The human practices project will be a compilation of creative works from each of our team members that addresses different issues and problems and conveys thoughts and ideas regarding the diverse aspects of synthetic biology and genetic engineering.
+This component will encourage thinking about modern biotechnology from different perspectives and promote the synthesis of viewpoints and notions of people from a broad range of backgrounds and disciplines.
 |[[Image:British_Columbia_team.png|right|frame|Your team picture]]
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