Team:Washington
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- | + | While vital to our quality of life, traditional antibiotics face the serious | |
+ | problems of widespread bacterial resistance and destruction of natural gut | ||
+ | flora - problems which call for improved twenty-first century antibiotics. | ||
+ | Using synthetic biology tools, we designed, built, and tested two new | ||
+ | systems to fight infections by both broad types of bacteria - Gram-positive | ||
+ | and Gram-negative. Our first project targets ''Bacillus anthracis'', the | ||
+ | Gram-positive pathogen that causes anthrax. We re-engineered an enzyme to | ||
+ | remove the pathogen's protective coating, rendering it defenseless against | ||
+ | the immune system. In our second project, we re-engineered and transplanted | ||
+ | a protein secretion system capable of combating Gram-negative bacteria into | ||
+ | ''E. coli''. This system was designed to target Gram-negative pathogens in a | ||
+ | modular and controllable fashion. These two systems are the vanguard of a | ||
+ | new era of antibiotics using the power of nature harnessed with the tools of | ||
+ | synthetic biology. | ||
+ | <!---------------------------------------PAGE CONTENT GOES ABOVE THIS----------------------------------------> | ||
- | == | + | <div style="text-align:left"> |
+ | <center> | ||
+ | '''[[Team:Washington/Gram_Negative|Gram(-) Therapeutic]]''' | ||
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+ | '''[[Team:Washington/Gram_Positive|Gram(+) Therapeutic]]''' | ||
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{{Template:Team:Washington/Templates/Footer}} | {{Template:Team:Washington/Templates/Footer}} |
Latest revision as of 01:14, 28 October 2010
While vital to our quality of life, traditional antibiotics face the serious
problems of widespread bacterial resistance and destruction of natural gut
flora - problems which call for improved twenty-first century antibiotics.
Using synthetic biology tools, we designed, built, and tested two new
systems to fight infections by both broad types of bacteria - Gram-positive
and Gram-negative. Our first project targets Bacillus anthracis, the
Gram-positive pathogen that causes anthrax. We re-engineered an enzyme to
remove the pathogen's protective coating, rendering it defenseless against
the immune system. In our second project, we re-engineered and transplanted
a protein secretion system capable of combating Gram-negative bacteria into
E. coli. This system was designed to target Gram-negative pathogens in a
modular and controllable fashion. These two systems are the vanguard of a
new era of antibiotics using the power of nature harnessed with the tools of
synthetic biology.