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Team:Washington
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| + | <area shape="rect" alt="Player 1 Gram(-)" title="Gram(-) Therapeutic" coords="343,281,493,300" href="https://2010.igem.org/Team:Washington/Gram_Negative"/> | ||
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| + | <br /> | ||
| + | While vital to our quality of life, traditional antibiotics face the serious | ||
| + | problems of widespread bacterial resistance and destruction of natural gut | ||
| + | flora - problems which call for improved twenty-first century antibiotics. | ||
| + | Using synthetic biology tools, we designed, built, and tested two new | ||
| + | systems to fight infections by both broad types of bacteria - Gram-positive | ||
| + | and Gram-negative. Our first project targets ''Bacillus anthracis'', the | ||
| + | Gram-positive pathogen that causes anthrax. We re-engineered an enzyme to | ||
| + | remove the pathogen's protective coating, rendering it defenseless against | ||
| + | the immune system. In our second project, we re-engineered and transplanted | ||
| + | a protein secretion system capable of combating Gram-negative bacteria into | ||
| + | ''E. coli''. This system was designed to target Gram-negative pathogens in a | ||
| + | modular and controllable fashion. These two systems are the vanguard of a | ||
| + | new era of antibiotics using the power of nature harnessed with the tools of | ||
| + | synthetic biology. | ||
| + | <!---------------------------------------PAGE CONTENT GOES ABOVE THIS----------------------------------------> | ||
| + | <div style="text-align:left"> | ||
| + | <center> | ||
| + | '''[[Team:Washington/Gram_Negative|Gram(-) Therapeutic]]''' | ||
| + | | ||
| + | '''[[Team:Washington/Gram_Positive|Gram(+) Therapeutic]]''' | ||
| + | </center> | ||
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Latest revision as of 01:14, 28 October 2010
While vital to our quality of life, traditional antibiotics face the serious
problems of widespread bacterial resistance and destruction of natural gut
flora - problems which call for improved twenty-first century antibiotics.
Using synthetic biology tools, we designed, built, and tested two new
systems to fight infections by both broad types of bacteria - Gram-positive
and Gram-negative. Our first project targets Bacillus anthracis, the
Gram-positive pathogen that causes anthrax. We re-engineered an enzyme to
remove the pathogen's protective coating, rendering it defenseless against
the immune system. In our second project, we re-engineered and transplanted
a protein secretion system capable of combating Gram-negative bacteria into
E. coli. This system was designed to target Gram-negative pathogens in a
modular and controllable fashion. These two systems are the vanguard of a
new era of antibiotics using the power of nature harnessed with the tools of
synthetic biology.
