Team:ZJU-China

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    <h1><b>Home</b></h1>
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    <p>&nbsp;&nbsp;&nbsp;&nbsp;Welcome to the homepage of ZJU-CHINA!</p>
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<p>&nbsp;&nbsp;&nbsp;&nbsp;we're igemers from team <strong>ZJU-China</strong>, who are young researchers in synthetic biology. It's our first time to take part in iGEM. We hope we can bring you a new brainstorm in iGEM2010! We love iGEM!
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<p>&nbsp;&nbsp;&nbsp;&nbsp;We're a team of 20 undergraduates from various disciplines and 2 instructors, and it's our first time to participate in this year's iGEM competition. Our project is Bach, a gene composer software that can tune the discordant codon bias into a consonant piece that better suits the host organism and performs translation process more predictably in terms of RiPS.</p>
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We'd like to share ideas with you. Here are our team's 3 primary projects.</p>
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    <p>&nbsp;&nbsp;&nbsp;&nbsp;Though we're young, we dare to create and adventure in synthetic biology. We hope to bring you inspiration as well as passion for new understandings and new standards in synthetic biology. </p>
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    <h2>Projects</h2>
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<h2 class="title">Project descriptions</h2>
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    <p>&nbsp;&nbsp;&nbsp;&nbsp;Sure you can't wait to see our project Bach, which can be directly downloaded from SOFTWARE, with a clear written manual for instruction. MODELING provides you with the mathematical model we've built to quantify translational behavior and serves as the underlying method for computation of RiPS in Bach. If you need more detailed translation process description and information concerning codon bias, please read BACKGROUND to better understand the whole project. SIGNIFCANCE shows the value of our work and will certainly make you inspired by the prospect of it! For improvements on Bach, NEXT GENERATION assures you of our determination and plan to make our composer a truly virtuoso.  
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    <h3>1. Biobrick optimizer</h3>
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<p>&nbsp;&nbsp;&nbsp;&nbsp;This project mainly targets at a quantitative analysis and prediction of translation rates through RIPS, ribosomal initiation per second, which hasn’t been well characterized and utilized in synthetic biology. Taking into consideration of codon usage, mRNA secondary structure, repetitive sequences and other main factors in this process, we aim to build a model on predicting translation rates through varying different levels of RIPS and correspondingly design certain software for application. Necessary experiments in wet lab would also be carried out for verification. We believe, by the combination of POPs and RIPs, the construction of a more predictable, complex and systematic genetic circuit would be possible, in which biobricks can be redesigned and optimized for the desired performance of the system quantitatively, another step towards standardization.</p><br>
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<h3>2. Auto-regulating biofuel machine</h3>
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    <h2>Activities</h2>
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<p>&nbsp;&nbsp;&nbsp;&nbsp;As fossil fuels are running out, more and more attention has been focused on the adoption of biofuel nowadays for relieving energy stress. Researchers have designed many modified microbial machines to produce fuels like hydrogen and ethanol. However, the lack of systematic reconstruction of microbes has made industrial fermentation incapable of regulating itself to promptly adapt to the changing environment.</p>
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    <p>&nbsp;&nbsp;&nbsp;&nbsp;HUMAN PRACTICE records our most profound thoughts and concerns about synthetic biology and our project, in which you can enjoy a fantastic and entertaining journey in our short fiction Redeem. In TEAM COOPERATION, we're grateful for all the help we've received from other iGEM teams and it's our great pleasure to be able to help them back and contribute a verse to the bigger family of iGEM competition. </p>
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                <p>&nbsp;&nbsp;&nbsp;&nbsp;We plan to design a microbial machine which can spontaneously regulate the production of fuel according to nutrients around it. The machine can use cellulose from periphery, decompose it to glucose with manipulated cellulose, ferment the glucose and finally produce fuels such as alcohol. We want to transfer a series of operons, sensitive to glucose, to control cellulose expression. The expression will be inhibited when excessive glucose present, more than what the bacteria could use for alcohol fermentation, while increased when little glucose present. By the control of this negative feedback, the amount of glucose generated from cellulose will be finally regulated to be as much as that converted to ethanol, in which we wish to find an equilibrium to maximize the transformation efficiency.</p><br>
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            <h3>3. Yeast olfactory sensing chip</h3>
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<p>&nbsp;&nbsp;&nbsp;&nbsp;We’re trying to make a yeast olfactory sensing chip by transferring olfactory G protein coupled receptors (GPCRs) from mammals into yeasts, S. cerevisiae, which would result in a membrane voltage shift that could be detected by the microelectrode. In theory, each GPCR responds to gas molecules of a specific structure category, yet each gas molecule may stimulate more than one type of GPCRs. Thus, an olfactory sensing chip could be constructed of yeasts expressing different GPCRs of our interest, which largely depends on its application, forming unique tiny cells of the same GPCR expression yeasts. In the meantime, a mathematical model would also be built for signal processing. Then, by reading different combinations of the outcome from the chip, we’d be able to actually smell through the yeasts and discern gases of our interest in the air. However, the major task lies in how to increase our detector’s sensitivity to make it more competitive with other e-noses, which we hope to cover in this summer’s work.</p>
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<h2>Team</h2> 
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<p>&nbsp;&nbsp;&nbsp;&nbsp;Want to meet cool members of our team? Don't even hesitate to see MEMBER INFO! Interested in our university? UNIVERSITY INFO can guide you through the excellence and the main things you need to know about our university. CITY INFO will be visual feast, showing you what a marvelously beautiful paradise we've living in. </p>
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<h2>Sponsors</h2>  
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<p>&nbsp;&nbsp;&nbsp;&nbsp;Huge thanks for our sponsors SUNNY NUTRITION, ZJU-IR and ZJU-CLS. Without their support, we wouldn't have possibly done the whole project or even participate in this year's iGEM competition in the first place. </p>
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Latest revision as of 17:44, 27 October 2010

Home

    Welcome to the homepage of ZJU-CHINA!

    We're a team of 20 undergraduates from various disciplines and 2 instructors, and it's our first time to participate in this year's iGEM competition. Our project is Bach, a gene composer software that can tune the discordant codon bias into a consonant piece that better suits the host organism and performs translation process more predictably in terms of RiPS.

    Though we're young, we dare to create and adventure in synthetic biology. We hope to bring you inspiration as well as passion for new understandings and new standards in synthetic biology.


Projects

    Sure you can't wait to see our project Bach, which can be directly downloaded from SOFTWARE, with a clear written manual for instruction. MODELING provides you with the mathematical model we've built to quantify translational behavior and serves as the underlying method for computation of RiPS in Bach. If you need more detailed translation process description and information concerning codon bias, please read BACKGROUND to better understand the whole project. SIGNIFCANCE shows the value of our work and will certainly make you inspired by the prospect of it! For improvements on Bach, NEXT GENERATION assures you of our determination and plan to make our composer a truly virtuoso.


Activities

    HUMAN PRACTICE records our most profound thoughts and concerns about synthetic biology and our project, in which you can enjoy a fantastic and entertaining journey in our short fiction Redeem. In TEAM COOPERATION, we're grateful for all the help we've received from other iGEM teams and it's our great pleasure to be able to help them back and contribute a verse to the bigger family of iGEM competition.


Team

    Want to meet cool members of our team? Don't even hesitate to see MEMBER INFO! Interested in our university? UNIVERSITY INFO can guide you through the excellence and the main things you need to know about our university. CITY INFO will be visual feast, showing you what a marvelously beautiful paradise we've living in.


Sponsors

    Huge thanks for our sponsors SUNNY NUTRITION, ZJU-IR and ZJU-CLS. Without their support, we wouldn't have possibly done the whole project or even participate in this year's iGEM competition in the first place.



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