Team:Purdue/Project

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====Project: Hypoxia-Sensitive Circuits====
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Low oxygen level, or hypoxic, environments are issues in both plant and mammalian systems.  From water-logged soils to overpopulated regions of tumors, hypoxic regions provide a niche for novel technologies to be put into place to exploit this condition.
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<span style="font-size:16px; font-family:georgia; border:2px solid black; padding: 6px; margin: 6px; margin-left:15px;">[[Team:Purdue|<span style="color:green;">Home</span>]]</span>
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Plants in areas with improper levels of oxygen will have to switch from aerobic respiration to lactic and then alcohol fermentation in order to sustain their metabolic processes.  Unfortunately this switch to alcohol fermentation will lead to the accumulation of byproducts that are detrimental to a plant’s life.  So a synthetic biological circuit centering on the Adh promoter has been developed to indicate when these low oxygen levels (less than 5% oxygen) are present. 
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<span style="font-size:16px; font-family:georgia; border:2px solid black; padding: 6px; margin: 6px;">[[Team:Purdue/Team|<span style="color:green;">The Team</span>]]</span>
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<span style="font-size:16px; font-family:georgia; border:2px solid black; padding: 6px; margin: 6px;">[[Team:Purdue/Project|The Project]]</span>
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Hypoxia is also very prevalent in densely populated regions of tumors. It is believed that these areas may initiate hypoxia-driven angiogenesis, a process which aides greatly in tumor proliferation.  Accordingly, an additional circuit has been created that will highlight the areas where hypoxic regions (less than 1% oxygen) have arisen during tumor development.  The development and characterization of these novel circuits will help to lay down foundation for potential remedies to these consequences of hypoxia in both mammalian and plant systems. 
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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
 
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''Tell us more about your project.  Give us background.  Use this is the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
 
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|align="center"|[[Team:Purdue | Team Example]]
 
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<!--- The Mission, Experiments --->
 
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!align="center"|[[Team:Purdue|Home]]
 
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!align="center"|[[Team:Purdue/Team|Team]]
 
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!align="center"|[https://igem.org/Team.cgi?year=2010&team_name=Purdue Official Team Profile]
 
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!align="center"|[[Team:Purdue/Project|Project]]
 
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!align="center"|[[Team:Purdue/Parts|Parts Submitted to the Registry]]
 
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!align="center"|[[Team:Purdue/Modeling|Modeling]]
 
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== '''Overall project''' ==
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{{Team:Purdue/link|Oxygen Sequestration Brainstorming & Thoughts}}
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Your abstract
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== Project Details==
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=== Part 2 ===
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=== The Experiments ===
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=== Part 3 ===
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== Results ==
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Latest revision as of 16:43, 26 July 2010

Purdue Banner.png


Home The Team The Project Parts Submitted to the Registry Modeling Notebook Safety Collaboration

Project: Hypoxia-Sensitive Circuits

Low oxygen level, or hypoxic, environments are issues in both plant and mammalian systems. From water-logged soils to overpopulated regions of tumors, hypoxic regions provide a niche for novel technologies to be put into place to exploit this condition.

Plants in areas with improper levels of oxygen will have to switch from aerobic respiration to lactic and then alcohol fermentation in order to sustain their metabolic processes. Unfortunately this switch to alcohol fermentation will lead to the accumulation of byproducts that are detrimental to a plant’s life. So a synthetic biological circuit centering on the Adh promoter has been developed to indicate when these low oxygen levels (less than 5% oxygen) are present.

Hypoxia is also very prevalent in densely populated regions of tumors. It is believed that these areas may initiate hypoxia-driven angiogenesis, a process which aides greatly in tumor proliferation. Accordingly, an additional circuit has been created that will highlight the areas where hypoxic regions (less than 1% oxygen) have arisen during tumor development. The development and characterization of these novel circuits will help to lay down foundation for potential remedies to these consequences of hypoxia in both mammalian and plant systems.




Oxygen Sequestration Brainstorming & Thoughts

Retrieved from "http://2010.igem.org/Team:Purdue/Project"