Team:Heidelberg
From 2010.igem.org
(Difference between revisions)
Line 154: | Line 154: | ||
One, we have developed a novel method for miRNA based gene expression tuning in mammalian cells, allowing the fine-tuning of gene expression based on synthetic miRNAs, as well as the cell specific on- and off-targeting based on endogenous miRNAs. We show that this method is functional in vivo and in vitro and prove the high potential of all three miRNA-based regulation approaches.<br> | One, we have developed a novel method for miRNA based gene expression tuning in mammalian cells, allowing the fine-tuning of gene expression based on synthetic miRNAs, as well as the cell specific on- and off-targeting based on endogenous miRNAs. We show that this method is functional in vivo and in vitro and prove the high potential of all three miRNA-based regulation approaches.<br> | ||
Two, we have developed a standardized and fast approach towards the creation of AAV-based gene delivery vectors. We have achieved exceptionally selective tissue-specific targeting <i>in vitro</i> and <i>in vivo</i> with hepatocyte specific delivery vectors.<br> | Two, we have developed a standardized and fast approach towards the creation of AAV-based gene delivery vectors. We have achieved exceptionally selective tissue-specific targeting <i>in vitro</i> and <i>in vivo</i> with hepatocyte specific delivery vectors.<br> | ||
- | We are happy to provide the synthetic biology community with two high impact innovations which will fuel the improvement of tissue specific gene therapy approaches and other medical applications of synthetic biology.</div><br> | + | We are happy to provide the synthetic biology community with two high impact innovations which will fuel the improvement of tissue specific gene therapy approaches and other medical applications of synthetic biology.</div><br><br> |
<div id="slider"> | <div id="slider"> | ||
Line 161: | Line 161: | ||
<a href="https://2010.igem.org/Team:Heidelberg/Project/miMeasure"><img src="https://static.igem.org/mediawiki/2010/e/ee/Slide_miMeasure.png" alt="" rel="https://static.igem.org/mediawiki/2010/f/f0/Slide_miMeasure_thumb.png"/></a> | <a href="https://2010.igem.org/Team:Heidelberg/Project/miMeasure"><img src="https://static.igem.org/mediawiki/2010/e/ee/Slide_miMeasure.png" alt="" rel="https://static.igem.org/mediawiki/2010/f/f0/Slide_miMeasure_thumb.png"/></a> | ||
<a href="https://2010.igem.org/Team:Heidelberg/Project/miMeasure"><img src="https://static.igem.org/mediawiki/2010/7/72/Slider_in_vivo.png" alt="" rel="https://static.igem.org/mediawiki/2010/a/a3/Slider_in_vivo_thumb.png"/></a> | <a href="https://2010.igem.org/Team:Heidelberg/Project/miMeasure"><img src="https://static.igem.org/mediawiki/2010/7/72/Slider_in_vivo.png" alt="" rel="https://static.igem.org/mediawiki/2010/a/a3/Slider_in_vivo_thumb.png"/></a> | ||
- | </div><br><br><br><br> | + | </div><br><br><br><br><br><br> |
Revision as of 03:59, 28 October 2010
|
|
||