Team:Washington

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While vital to our quality of life, traditional antibiotics face the serious
While vital to our quality of life, traditional antibiotics face the serious
problems of widespread bacterial resistance and destruction of natural gut
problems of widespread bacterial resistance and destruction of natural gut
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the immune system.  In our second project, we re-engineered and transplanted
the immune system.  In our second project, we re-engineered and transplanted
a protein secretion system capable of combating Gram-negative bacteria into
a protein secretion system capable of combating Gram-negative bacteria into
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E. coli.  This system was designed to target Gram-negative pathogens in a
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''E. coli''.  This system was designed to target Gram-negative pathogens in a
modular and controllable fashion.  These two systems are the vanguard of a
modular and controllable fashion.  These two systems are the vanguard of a
new era of antibiotics using the power of nature harnessed with the tools of
new era of antibiotics using the power of nature harnessed with the tools of
synthetic biology.
synthetic biology.
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'''[[Team:Washington/Gram_Negative|Gram(-) Therapeutic]]'''
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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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'''[[Team:Washington/Gram_Positive|Gram(+) Therapeutic]]'''
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'''[[Team:Washington/Gram Negative|Overview of the Gram(-) Therapeutic]]&rarr;'''
 
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Latest revision as of 01:14, 28 October 2010

21stCenturyAntibioticsBanner START button Player 1 Gram(-) Player 2 Gram(+) Gram(+) Side Gram(-) Side


While vital to our quality of life, traditional antibiotics face the serious problems of widespread bacterial resistance and destruction of natural gut flora - problems which call for improved twenty-first century antibiotics. Using synthetic biology tools, we designed, built, and tested two new systems to fight infections by both broad types of bacteria - Gram-positive and Gram-negative. Our first project targets Bacillus anthracis, the Gram-positive pathogen that causes anthrax. We re-engineered an enzyme to remove the pathogen's protective coating, rendering it defenseless against the immune system. In our second project, we re-engineered and transplanted a protein secretion system capable of combating Gram-negative bacteria into E. coli. This system was designed to target Gram-negative pathogens in a modular and controllable fashion. These two systems are the vanguard of a new era of antibiotics using the power of nature harnessed with the tools of synthetic biology.


Gram(-) Therapeutic                  Gram(+) Therapeutic


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