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Team:BCCS-Bristol/Modelling/GRN/Derivation
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A Gene Regulatory Network (GRN) model is an established way of representing the biochemical reactions within a bacterial cell [[(7)]]. Representing a network of interacting components using differential equations can be very useful, mainly because one can make analytical and qualitative assessments of a system’s behaviour with very limited information on parameters. This GRN represents a protein called NsrR that represses the production of mRNA encoding GFP, and so indirectly repressing the production of GFP. NsrR can bind to nitrates, effectively destroying its ability to repress the system. | A Gene Regulatory Network (GRN) model is an established way of representing the biochemical reactions within a bacterial cell [[(7)]]. Representing a network of interacting components using differential equations can be very useful, mainly because one can make analytical and qualitative assessments of a system’s behaviour with very limited information on parameters. This GRN represents a protein called NsrR that represses the production of mRNA encoding GFP, and so indirectly repressing the production of GFP. NsrR can bind to nitrates, effectively destroying its ability to repress the system. | ||
| - | [[Image:GRN.jpg| | + | [[Image:GRN.jpg|frameless|center|upright=4|agrEcoli Gene Regulatory Network Equations]] |
Revision as of 15:24, 18 October 2010
BCCS-Bristol
iGEM 2010
iGEM 2010
Derivation
Discussion of how we derived GRN model....
GRN Models
A Gene Regulatory Network (GRN) model is an established way of representing the biochemical reactions within a bacterial cell (7). Representing a network of interacting components using differential equations can be very useful, mainly because one can make analytical and qualitative assessments of a system’s behaviour with very limited information on parameters. This GRN represents a protein called NsrR that represses the production of mRNA encoding GFP, and so indirectly repressing the production of GFP. NsrR can bind to nitrates, effectively destroying its ability to repress the system.
