Team:TU Delft/Modeling/MFA/PHB
From 2010.igem.org
PHB production
In previous situations the hydrocarbons were degraded only to form biomass and CO2. It is interesting to see how much product could be made from hydrocarbons. PHB is a polymer of polyhydroxybutyrate. The production pathway of PHB is well known. PHB is a solid product which is to recover in the down stream process.
The pathway is displayed here http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY1-3&detail-level=2&detail-level=1
In this scenario the lumped PHB production pathway was added to metabolic network;
2 acetyl-CoA + NADPH -> (R)-3-hydroxybutanoyl-CoA the polymerization reaction just consumes (R)-3-hydroxybutanoyl-CoA.