Team:WITS-South Africa/The Problem

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The development of a whole-cell biosensor for the immediate, in vivo detection of Human Papillomavirus (HPV), in the form of an engineered commensal vaginal bacterium. This mechanism would be safe, low-cost and easily administrable; and is intended primarily for women in resource-poor settings.

The link between HPV and cervical cancer is well-established. Although much progress has been made in developing a vaccine, the vaccines that are currently available have some limitations (mainly due to high cost and inadequate accessibility) in their ability to prevent disease burden in developing countries, where 80% of cervical cancer deaths occur annually.

This inspired the search for a method of detecting the virus that will alert the infected individual in a discreet yet persistent manner. The machine would also have the potential to be further adapted to have the ability to neutralise the virus and prevent the infection from spreading. Basically, the machine that we wish to design will be able to detect an infectious agent and inform neighbouring bacteria - as well as the host - as to the presence of that pathogen.