Vision and concept

Although classical molecular biology and genetic engineering equipped the science community with many functional proteins and possible applications, usage and linking different parts together to a working network still requires highly complicated strategies. Often the assembly of different biological parts tends to be error-prone and very difficult to extend since only few switches are established and studied in a way that they deliver reliable basic units. Even those like the ultimate protein expression control unit, the lac operon, are limited: With the lac operon only 0 and 1 can be achieved and only once per expression construct and cell. Our approach is to change that and to enable new and more exact ways to control E. coli cells using RNA-RNA-interaction based switches.

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