Team:Imperial College London/Modelling/Signalling
From 2010.igem.org
Signalling Model |
Objectives |
Detailed description |
We assuming steady-state for AIP, Phosphate, ComD and ComE in our cell/in the solution. Hence, we can neglect production and degradation rates of ComD and ComE. |
Equation 1: AIP binds to ComD receptor to form a complex (AIP-ComD) |
AIP + ComD ↔ AIP-ComD |
Equation 2: Phosphate binds to the AIP-ComD complex to form another complex (AIP-ComD*) |
AIP-ComD + Phosphate ↔ AIP-ComD* |
Equation 3: ComE binds to the AIP-ComD* recepetor to form another complex (AIP-ComD*-ComE) |
AIP-ComD* + ComE ↔ AIP-ComD*-ComE |
Equation 4: Phosphate group on ComD binds to ComE and forms two products: phosphorylated ComE (ComE*) and AIP-ComD |
AIP-ComD*-ComE ↔ AIP-ComD + ComE* |
Parameters & Constants |
Results |
Download Matlab files |
Using the Law of Mass Action, we can rewrite these 4 equations: |