Team:Imperial College London/Modelling/Signalling

From 2010.igem.org

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|We assuming steady-state for AIP, Phosphate, ComD and ComE in our cell/in the solution. Hence, we can neglect production and degradation rates of ComD and ComE.
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|'''Equation 1:''' AIP binds to ComD receptor to form a complex (AIP-ComD)
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|AIP + ComD <html>&harr;</html> AIP-ComD
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|'''Equation 2:''' Phosphate binds to the AIP-ComD complex to form another complex (AIP-ComD*)
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|AIP-ComD + Phosphate <html>&harr;</html> AIP-ComD*
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|'''Equation 3:''' ComE binds to the AIP-ComD* recepetor to form another complex (AIP-ComD*-ComE)
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|AIP-ComD* + ComE <html>&harr;</html> AIP-ComD*-ComE
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|'''Equation 4:''' Phosphate group on ComD binds to ComE and forms two products: phosphorylated ComE (ComE*) and AIP-ComD
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|AIP-ComD*-ComE <html>&harr;</html> AIP-ComD + ComE*
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|<html><h2>Parameters & Constants</h2></html>
|<html><h2>Parameters & Constants</h2></html>

Revision as of 15:13, 24 October 2010

Signalling Model

Objectives

Detailed description

We assuming steady-state for AIP, Phosphate, ComD and ComE in our cell/in the solution. Hence, we can neglect production and degradation rates of ComD and ComE.
Equation 1: AIP binds to ComD receptor to form a complex (AIP-ComD)
AIP + ComD ↔ AIP-ComD
Equation 2: Phosphate binds to the AIP-ComD complex to form another complex (AIP-ComD*)
AIP-ComD + Phosphate ↔ AIP-ComD*
Equation 3: ComE binds to the AIP-ComD* recepetor to form another complex (AIP-ComD*-ComE)
AIP-ComD* + ComE ↔ AIP-ComD*-ComE
Equation 4: Phosphate group on ComD binds to ComE and forms two products: phosphorylated ComE (ComE*) and AIP-ComD
AIP-ComD*-ComE ↔ AIP-ComD + ComE*

Parameters & Constants

Results

Download Matlab files

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