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Team:Freiburg Bioware/Modelling
From 2010.igem.org
(Difference between revisions)
| Line 8: | Line 8: | ||
For the modeling part we considered the three main parts: | For the modeling part we considered the three main parts: | ||
<ul> | <ul> | ||
| - | <li> | + | <li>the virus production |
<li>the infection of a target cell | <li>the infection of a target cell | ||
<li>the therapy | <li>the therapy | ||
</ul> | </ul> | ||
| - | For the first two models we assumed reactions according to the law of mass action to create | + | For the first two models we assumed reactions according to the law of mass action to create a model of ordinary differential equations (ODE). |
<br><br> | <br><br> | ||
| Line 18: | Line 18: | ||
<br><br> | <br><br> | ||
<h3>Reaction Scheme</h3> | <h3>Reaction Scheme</h3> | ||
| + | The reaction scheme for the virus production is considered as follows:<br> | ||
| + | In the extracellular medium is a starting concentration of the four principle plasmids - the plasmid coding for the <b>helper proteins</b> (<i>helper</i>), the <b>gene of interest</b> (<i>goi</i>) and two types of DNA coding for the <b>capsid proteins</b> (<i>capwt</i> [wild type], <i>capmod</i> [modified]). | ||
| + | |||
<center> | <center> | ||
<img width="733" height="966" src="https://static.igem.org/mediawiki/2010/b/b8/Freiburg10_VirusProduction01.png" alt="Reaction scheme for the virus production" /> | <img width="733" height="966" src="https://static.igem.org/mediawiki/2010/b/b8/Freiburg10_VirusProduction01.png" alt="Reaction scheme for the virus production" /> | ||
Revision as of 15:33, 21 October 2010
Modeling
For the modeling part we considered the three main parts:- the virus production
- the infection of a target cell
- the therapy
Model for Virus Production
Reaction Scheme
The reaction scheme for the virus production is considered as follows:In the extracellular medium is a starting concentration of the four principle plasmids - the plasmid coding for the helper proteins (helper), the gene of interest (goi) and two types of DNA coding for the capsid proteins (capwt [wild type], capmod [modified]).
Reduced Reaction Scheme
Differential Equations
Model for Virus Infection
Reaction Scheme
Reduced Reaction Scheme
Differential Equations
