Team:Brown/Modeling/Parameters

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Parameters

As our circuit is relatively complex, we have many factors and thus many parameters with which to describe the function of these factors mathematically. These parameters are as follows: #δ is a function designed to represent the presence/absence of light in a Boolean fashion. δ=0 without light and 1 with light. #c_1 represents the rate of conformational change from LovTAP to LovTAP* when irradiated with 470nm light. #c_2 represents the rate of SupD + T7ptag  T7 polymerase #α represents the maximum protein synthesis rate in nanomoles/min. #β represents the basal synthesis rate. We assume ∀x β_x= .01α_x #μ represents the protein degradation rate. #n represents a ligand’s hill coefficient. #K_m represents the ligand’s dissociation constant

For a complete list of values and sensitivities, please see attached spreadsheet .