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Team:Northwestern/Brainstorm
From 2010.igem.org
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Round 1: Group Brainstorming Session
Health/Medicine
Release in presence of wound signal (pH) Factor VIII Symbiosis with human body Selective phagocytosis (absorb toxin) Selective phagocytosis (lead) Phagocytosis for drug overdoses Drug sensing bactera Bacterial spermicide Drug delivery method through WBC Apoptosis with drug delivery when disease is recognized Vitamin and mineral delivery Bacteria that takes up excess ions in the body Self Healing material: growth factor Apoptosis in presence of a particular disease Swine Flu testing on site Target bad cells selectively based on offset in circadian rythmn Cure celiac’s with bacteria Ethrypoeitin production in e. coli Thrombolytics in presence in LDL Thrombolytics in precense of clots (macrophages) Bacterial pacemakers
Food/Energy
Supplementary vitamin and minerals to be grown on produce Removable pesticide bacterial film Cheese reservatrol Splitting Hydrogen from water Electrogenesis: produce voltage from bacteria
Environment
Consume gases in the air (ozone) Consume (CFCs) On site radiation testing (make it click like a Geiger counter) Breaking down plastics (look at past presentation) Photo-driven battery
Manufacturing/Industrial
Trace explosive Bacteria EXPLODING BACTERIA Bacterial Superglue Resistors Capacitors (Storing charge) Phagocytosis for water in shoes Bacterial barometer Bacterial paper to print on Active pH buffer for e. coli (target pH) pH meter Cilia creating fluid flow, generating fluid current Create ferrofluuid to create magnetism Bacteria to regulate the temperature of a surface (endothermic and exothermic reaction) Long lasting bacterial sunblock Bacterial Clothing Thermal heating for toes Adjusting Young’s Modulus Contracting group of cells Thermometer Bacterial film that responds to laser so you can sketch on it. (express GFP light induced promoter) Bacterial Gears
Miscellaneous
ELISA for DNA ELISA for mRNA Magnetic Bacteria Faster biodegradation (Signal activated ) (isn't this environmental?) Oncoprotein expressed on the outside missing ligand binding portion Cytoskeleton in bacteria Engineering current flow intracellularly Bacterial gyroscope Bacterias that produce primers Proteosome into e. coli design system to keep at steady state to keep e. coli alive Nail polish (grow back or fade away) Tight junctions into bacteria Synthetic Apoptotic signal (and isn't this medical?) Music Playing Bacteria: loudspeaker Clock using bacterial gears Non Newtonian fluid bacteria (using force) Bacteria piston using sinking and floating mechanism Gap junction music playing Rotifers: surviving without water mechanism (protein protection) Engineering signal glycoproteins into bacteria (integration of virus disrupts reporter gene)
Round 2: Official 2010 iGEM Draft
Each member chose 3 favorite topics to research
Sean - Opsin, Electrogenesis, Tight Junction
Avi - Proteosome, Storing Charge, Magnetic Field
Ben - Pacemaker, Factor8, Excess Ion uptake
Matt - Self Healing Material, WBC, Bacterial Thermometer
Timi - Splitting Water, Primer Production, Oncoprotein Express
Jeremy - Circadian Rhythm, pH meter, Cytoskeleton
Ragan - Selective Phagocytosis, Erythropoietin Production, Inducible Apoptosis
Round 3: Presentation and Voting
Voted on the basis of: Sexiness, Available Parts, Feasibility, and Applications
Narrowed Down to: Cytoskeleton, Magnetic Bacteria, and Self Healing Armor
Round 4: Group Discussion
Cytoskeleton Discarded
Self-Healing Armor altered to Bacterial Skin
B-Cell/T-Cell Response Modeling Introduced
Magnetic Bacteria relegated to side project
Round 5: Presentation and Final Voting
Main Project: Bacterial Skin
Side Project: Magnetic Bacteria (Magnetite Synthesis)
