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Project descriptions:

1. Biobrick optimizer

This project mainly targets at a quantitative analysis and prediction of translation rates through RIPS, ribosomal initiation per second, which hasn’t been well characterized and utilized in synthetic biology. Taking into consideration of codon usage, mRNA secondary structure, repetitive sequences and other main factors in this process, we aim to build a model on predicting translation rates through varying different levels of RIPS and correspondingly design certain software for application. Necessary experiments in wet lab would also be carried out for verification. We believe, by the combination of POPs and RIPs, the construction of a more predictable, complex and systematic genetic circuit would be possible, in which biobricks can be redesigned and optimized for the desired performance of the system quantitatively, another step towards standardization.

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[=level 1=]fatestudio!