Team:UT-Tokyo/Allergy abstract

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Abstract     
Abstract     
[https://2010.igem.org/Team:UT-Tokyo/Allergy_construct  Construct]     
[https://2010.igem.org/Team:UT-Tokyo/Allergy_construct  Construct]     
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[https://2010.igem.org/Team:UT-Tokyo/Allergy_experiment  Experiment]   
 
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[https://2010.igem.org/Team:UT-Tokyo/Allergy_notebook  Notebook]   
 
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[https://2010.igem.org/Team:UT-Tokyo/Allergy_result  Result]
 
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<h2>'''Abstract'''</h2>
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== '''Abstract''' ==
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We're trying to make ''E.coli'' solve Sudoku puzzle. Human and Computers can solve Sudoku, of course. But ''E.coli'', A lot of people are suffering from allergy every year. People sneeze and have trouble in stuffy nose because of house dust or pollen etc. Here, we mainly focus on the pollen allergy that is causing serious problems in many countries. To tackle on this problem, we use hyposensitization therapy which makes our body accustom to antigens by intaking them little by little every day. Our E.coli will constantly produce epitopes in our intestines, and the epitopes will be recognized by antibody. Here, we use epitopes of cedar pollen, but this method can be used in other types of allergy and we hope this method will be useful to cure allergy fundamentally.  
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==='''Making the desensitization immunotherapy super-efficient'''===
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There are lots of people over the world suffering allergic disease, and numerous therapies being developed. In recent years, fundamental treatment called specific oral tolerance induction (SOTI) has been developed, which is different from conventional treatment. The intention of the fundamental treatment is to “dull” the immune system inside intestines by inducing epitope (the recognition site of allergen) deliberately and consecutively. Our goal is to design and build the system of the treatment by bio-brick, put it into E.coli and operate them in the living cells, implement them as an effective drug.
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== Appeal point ==
 
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==='''“Grasp the situation outside and think by themselves”: ideal drugs'''===
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In current SOTI, patients have to intake the epitope every day. However, by inputting the system original to creatures like “secret epitopes constantly”, and “output flexibly by sensing the situation outside”, we can make a new remedy with fewer side effects and less burdens for patients – the ideal allergy drug which can “grasp the situation outside, and think by themselves”. First, we will make E.coli able to secret epitopes constantly. Because E.colis can settle in our intestines for a long period, once we took drug, they’ll settle in our intestines, constantly secret epitopes. This will set us free form taking drugs every day and lessen the frequency of administration remarkably.
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== Future vision ==
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Moreover, we make E.colis able to increase the amount of epitopes secretion according to signals from outside. By this system, we can realize the step – increase the intake of epitopes gradually - which is essential to desensitization immunotherapy with no further burden.
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In case that side effect was occurred by over-secretion of epitopes, we need to stop the production of epitopes immediately. We are going to make E.colis able to “decide to stop” the production. Input the fail safe system of sensing the inflammatory cytokine and stop the product of epitopes automatically into E.colis, we can make practical drugs able to think.
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==='''The possibility of order-made therapy'''===
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The system we are making can be a universal allergic therapy easily, by changing the epitope to the other according to the types of allergy. For example, if you have shrimp allergy and pollen allergy, you can use epitope of shrimp and pollen to treat your allergy with pinpoint precision.
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When this therapy comes to the practical step, we can do the desensitization immunotherapy safely by extracting E.colis in patient intestines, introduce the genes and replace them to intestines without collapsing balances of intestine E.coli colonies and immune system. By such made-to-order therapy, we think  we can realize an ideal allergy therapy.
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Latest revision as of 22:54, 27 October 2010

UT-Tokyo

Allergy

Abstract Construct

Abstract

Making the desensitization immunotherapy super-efficient

There are lots of people over the world suffering allergic disease, and numerous therapies being developed. In recent years, fundamental treatment called specific oral tolerance induction (SOTI) has been developed, which is different from conventional treatment. The intention of the fundamental treatment is to “dull” the immune system inside intestines by inducing epitope (the recognition site of allergen) deliberately and consecutively. Our goal is to design and build the system of the treatment by bio-brick, put it into E.coli and operate them in the living cells, implement them as an effective drug.


“Grasp the situation outside and think by themselves”: ideal drugs

In current SOTI, patients have to intake the epitope every day. However, by inputting the system original to creatures like “secret epitopes constantly”, and “output flexibly by sensing the situation outside”, we can make a new remedy with fewer side effects and less burdens for patients – the ideal allergy drug which can “grasp the situation outside, and think by themselves”. First, we will make E.coli able to secret epitopes constantly. Because E.colis can settle in our intestines for a long period, once we took drug, they’ll settle in our intestines, constantly secret epitopes. This will set us free form taking drugs every day and lessen the frequency of administration remarkably.

Moreover, we make E.colis able to increase the amount of epitopes secretion according to signals from outside. By this system, we can realize the step – increase the intake of epitopes gradually - which is essential to desensitization immunotherapy with no further burden.

In case that side effect was occurred by over-secretion of epitopes, we need to stop the production of epitopes immediately. We are going to make E.colis able to “decide to stop” the production. Input the fail safe system of sensing the inflammatory cytokine and stop the product of epitopes automatically into E.colis, we can make practical drugs able to think.


The possibility of order-made therapy

The system we are making can be a universal allergic therapy easily, by changing the epitope to the other according to the types of allergy. For example, if you have shrimp allergy and pollen allergy, you can use epitope of shrimp and pollen to treat your allergy with pinpoint precision.

When this therapy comes to the practical step, we can do the desensitization immunotherapy safely by extracting E.colis in patient intestines, introduce the genes and replace them to intestines without collapsing balances of intestine E.coli colonies and immune system. By such made-to-order therapy, we think we can realize an ideal allergy therapy.



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