Team:Stockholm/9 August 2010

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(New page: {{Stockholm/Top2}} __TOC__ == Hassan == === Folate === below links and articles are meant to be study when I'm finished with interaction map and prove of concept! * [http://www.ncbi.nl...)
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* increase in SOD (SOD3) : [http://www.ncbi.nlm.nih.gov/pubmed/12692376]
* increase in SOD (SOD3) : [http://www.ncbi.nlm.nih.gov/pubmed/12692376]
* possible genes involved in Melanocytes adhesion: "An imbalance in cell adhesion molecules was also observed in vitiligo melanocytes. Differentially downregulated genes in vitiligo melanocytes included integrin alpha 7, integrin beta-like 1, integrin beta 7 and catenin alpha-like 1 (cadherin-associated protein). The adhesion between the melanocytes and the basal membrane is mediated by integrins and the contacts between melanocytes and keratinocytes are mediated by cadherins (Hara et al., 1994; Tang et al., 1994; Zambruno et al., 1993). The importance of regulated expression levels of cadherins have also been shown during migration of melanoblasts (Nishimura et al., 1999). It is difficult to predict if this specific downregulation of adhesion molecules impairs the attachment of the melanocytes in the basal layer of the epidermis; however, detachment and transepidermal loss of melanocytes have previously been reported in vitiligo vulgaris (Gauthier et al., 2003)."[http://www.ncbi.nlm.nih.gov/pubmed/18426409]  May also look at [http://www.ncbi.nlm.nih.gov/pubmed/17850512] if more interested.
* possible genes involved in Melanocytes adhesion: "An imbalance in cell adhesion molecules was also observed in vitiligo melanocytes. Differentially downregulated genes in vitiligo melanocytes included integrin alpha 7, integrin beta-like 1, integrin beta 7 and catenin alpha-like 1 (cadherin-associated protein). The adhesion between the melanocytes and the basal membrane is mediated by integrins and the contacts between melanocytes and keratinocytes are mediated by cadherins (Hara et al., 1994; Tang et al., 1994; Zambruno et al., 1993). The importance of regulated expression levels of cadherins have also been shown during migration of melanoblasts (Nishimura et al., 1999). It is difficult to predict if this specific downregulation of adhesion molecules impairs the attachment of the melanocytes in the basal layer of the epidermis; however, detachment and transepidermal loss of melanocytes have previously been reported in vitiligo vulgaris (Gauthier et al., 2003)."[http://www.ncbi.nlm.nih.gov/pubmed/18426409]  May also look at [http://www.ncbi.nlm.nih.gov/pubmed/17850512] if more interested.
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And those from [https://2010.igem.org/Team:Stockholm/22_July_2010 July 22] with data from [https://2010.igem.org/Team:Stockholm/Planning planning] will bring enough explanation for interaction map.
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I think by end of this week a wall of text will appear in modelling page!

Revision as of 16:45, 9 August 2010

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Contents


Hassan

Folate

below links and articles are meant to be study when I'm finished with interaction map and prove of concept!

Possible Genes

  • decrease in CAT (Catalase) : [7][8]
  • increase in SOD (SOD3) : [9]
  • possible genes involved in Melanocytes adhesion: "An imbalance in cell adhesion molecules was also observed in vitiligo melanocytes. Differentially downregulated genes in vitiligo melanocytes included integrin alpha 7, integrin beta-like 1, integrin beta 7 and catenin alpha-like 1 (cadherin-associated protein). The adhesion between the melanocytes and the basal membrane is mediated by integrins and the contacts between melanocytes and keratinocytes are mediated by cadherins (Hara et al., 1994; Tang et al., 1994; Zambruno et al., 1993). The importance of regulated expression levels of cadherins have also been shown during migration of melanoblasts (Nishimura et al., 1999). It is difficult to predict if this specific downregulation of adhesion molecules impairs the attachment of the melanocytes in the basal layer of the epidermis; however, detachment and transepidermal loss of melanocytes have previously been reported in vitiligo vulgaris (Gauthier et al., 2003)."[10] May also look at [11] if more interested.


And those from July 22 with data from planning will bring enough explanation for interaction map.

I think by end of this week a wall of text will appear in modelling page!

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