Team:Purdue/Oxygen Sequestration Brainstorming & Thoughts

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This video seems like a good review/introduction to the Calvin cycle.


Note from Professor Rickus

Okay. So I am pretty out of my element with plants. That is OK!! But it means you are going to need to add some plant experts to your advisors. Don't forget about Dr. Evans and friends at Dow Agro.

Some of you are also looking to how you could link this with cancer. Sean and Aaron are a Cancer DURIs for example. Sung has a basic interest. etc etc.

So I am actually thinking that there is A LOT you could do using this O2 sensitive transcription circuit in cancer! One thing cancer cells are really good at is surviving and adapting to hypoxic environments. In addition, the human cancer stem cells we have in the lab have been shown to be sensitive to their oxygen environments.

I think there is potential in oxygen sensitive transcription.



Add your thoughts below

I will look into profs in Hort. that have related experience. Landon, 5/30/10

There are lots of oxygen binding proteins that exist in nature. I even found a synthetic one, coboglobin, that utilizes cobalt instead of iron. So I don't think we should limit ourselves to just using hemoglobin. John mentioned leghemoglobin which I think is a good idea to look into because its natures way of solving a similar problem. Leghemoglobin binds oxygen so that the enzyme nitrogenase, which doesn't work well when oxygenated, can function properly. We could also use myoglobin which is similar to hemoglobin but its a less complex molecule. Also, the purpose of myoglobin is to store oxygen rather than transport it so it might work better than hemoglobin because we are only trying to sequester oxygen rather than transport it.---MJG, 06/01/2010.

insert brainstorming ideas within these, initial and date (?)



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