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From 2010.igem.org

Project abstract

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E-Lemming

This years ETHZ Basel project goal is to control E.coli chemotaxis by hijacking and perturbing the tumbling / directed flagellar movement apparatus. By coupling directed flagellar movement regulating proteins to a light-sensitive spatial localization system, their activity can be controlled reversibly. A light-sensitive dimerizing complex fused to this regulating proteins and a spatial fixed location is induced by light pulses and therefore localization of the two molecules can be manipulated. Tumbling / directed flagellar movement rates are supervised by image processing algorithms, which are linked to the light-pulse generator. This system enables to control single E.coli cells to move like mindless "Lemmings" in the direction they are forced to go.

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