Team:Cambridge/Quiescence

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=Quiescence=
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{{:Team:Cambridge/Templates/headerbar|colour=#fb5c2b|title=Shelved project: Quiescence}}
This Project seeks to design a device that can be used to switch cells into a non-growing, but metabolically active state. A system like this would be highly desirable, as it could be used to increase the efficiency of expression of plasmid genes. Quiescence would be a useful safeguard against loss of plasmids, which can cause the culture to be overgrown by plasmid-free bacteria. It could also help to reduce the frequency of undesirable mutations and provide a supplementary bio-safety mechanism, if escaping bacteria were unable to replicate.
This Project seeks to design a device that can be used to switch cells into a non-growing, but metabolically active state. A system like this would be highly desirable, as it could be used to increase the efficiency of expression of plasmid genes. Quiescence would be a useful safeguard against loss of plasmids, which can cause the culture to be overgrown by plasmid-free bacteria. It could also help to reduce the frequency of undesirable mutations and provide a supplementary bio-safety mechanism, if escaping bacteria were unable to replicate.
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==Intellectual Property==
==Intellectual Property==
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Using Rcd in the h-ns mutant to induce quiescence in E.coli is the Intellectual Property of Cambridge Microbial technologies. Dr Summers has been very supportive and we are going to continue the project. However, the legal issues have not been completely resolved yet. We still need to talk to Robert Hulme, the co-holder of the patent.  
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Using Rcd in the h-ns mutant to induce quiescence in E.coli is the Intellectual Property of Cambridge Microbial technologies. Dr Summers and Dr Hulme have been very supportive.
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==Further notes==
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Rough notes are available [https://2010.igem.org/Team:Cambridge/Quiescence_Notes here].
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Latest revision as of 23:55, 16 August 2010