Team:Calgary/Modelling/Maya

From 2010.igem.org

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<p>This is what we hope to show:
<p>This is what we hope to show:
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# A polypeptide chain is produced from a ribosome during translation.
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# A misfolded protein forms, exposing hydrophobic side chains.
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# This chain floats out into the cytoplasm (or periplasm) and begins to fold.
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# A nucleus of aggregation is formed by a collection of these misfolded proteins sticking together.
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# The chain folds into a functional stable protein.
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# More misfolded protein become attracted to the nucleus, attempting to "cover up" hydrophobic ends.
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# H+ ions (due to pH) come and interact with the side chains of the protein.
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# This process continues until a large inclusion body forms in the cell.
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# The protein turns inside-out, exposing its hydrophobic sides. It is not stable.
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# Hydrophobic unstable proteins are attracted to one another, joining together to minimalize the hydrophobicity of the main body.
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# This process continues as more unstable proteins are attracted to this growing insoluble mass. This is an inclusion body.
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Revision as of 22:35, 12 October 2010

Maya Animations

For our animation project, we are using Maya, a 3D graphics and animation program provided to us by Autodesk, which is a sponsor of iGEM this year. We intend to create an animation visualizing what the process of inclusion body formation might look like. The basis of this animation will be the reactions in our proposed MATLAB model. We believe this animation will help students in iGEM visualize and understand the process behind inclusion body formation. A dynamic visual catches people's attention and shows things as they happen, rather than showing static intermediate images on a diagram.

This is what we hope to show:

  1. A misfolded protein forms, exposing hydrophobic side chains.
  2. A nucleus of aggregation is formed by a collection of these misfolded proteins sticking together.
  3. More misfolded protein become attracted to the nucleus, attempting to "cover up" hydrophobic ends.
  4. This process continues until a large inclusion body forms in the cell.

Stay tuned to see this animation up and running!