Artificial biomanufacturing intelligence system ABIS

Synthetic biology is now in a position to overcome many, hitherto, cumbersome and resource consuming manufacturing tasks. Society has now accepted the advent of such entities as recombinant insulin , monoclonal antibodies etc as essential for the future well being of human life. We can now use the bio engineered tools available to us to create systems which make manufacturing health or environmentally associated products simpler and more economical.

To this end, this project addresses the hypothesis that we can use auto-induction as a means of control of production of recombinant products at a pre-destined time in large production vessels thus alleviating the need for extra resources. To illustrate this we are using E.coli as our main vehicle with the prospect of removing the need for IPTG induction as a mechanism for the production of a vast array of biopharmaceuticals. We expect this technology to be equally applicable to other systems such as yeast and mammalian cells.

Team

We are an interdisciplinary team spearheaded by the Biochemical Engineering Department in partnership with the Biochemistry department.