From 2010.igem.org
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Our project:
Our team wants to help stopping the propagation of malaria, a disease which has a death toll of over a million per year.
Malaria is transmitted by the parasite Plasmodium whose life cycle is well-studied: The mosquitoes are the vectors which propagate the infection to humans. The infected human will then again infect mosquitoes consuming a blood meal which then completes the cycle.
Bacteria of the genus Asaia have been proven to be stably associated to a malaria propagating mosquitoe, Anopheles stephensi [1]. We plan to take advantage of this and use engineered Asaia to block the Plasmodium cycle.
'Our progess:'
We are now in our first week in the wet lab. Apart from training basic lab skills like making a PCR and running a gel we are growing Asaia and studying its properties. Furthermore we finished our first biobrick containing an origin of replication for Asaia.
Within the next week we also plan to test the propagation of Asaia within Drosophila.
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... and become a fan of our team on facebook:
http://www.facebook.com/pages/EPFL-iGEM/117887404918202
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